butyrin
butyrin structure
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Common Name | butyrin | ||
|---|---|---|---|---|
| CAS Number | 60-01-5 | Molecular Weight | 302.363 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 307.5±0.0 °C at 760 mmHg | |
| Molecular Formula | C15H26O6 | Melting Point | -75 °C | |
| MSDS | Chinese USA | Flash Point | 173.9±0.0 °C | |
Use of butyrinTributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed prodrug of Butyric Acid. Tributyrin diffuses through biological membranes and is metabolized by intracellular lipases, releasing effective butyrate directly into the cell in vivo. Tributyrin has potent antiproliferative, proapoptotic and differentiation-inducing effects[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | tributyrin |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed prodrug of Butyric Acid. Tributyrin diffuses through biological membranes and is metabolized by intracellular lipases, releasing effective butyrate directly into the cell in vivo. Tributyrin has potent antiproliferative, proapoptotic and differentiation-inducing effects[1]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 307.5±0.0 °C at 760 mmHg |
| Melting Point | -75 °C |
| Molecular Formula | C15H26O6 |
| Molecular Weight | 302.363 |
| Flash Point | 173.9±0.0 °C |
| Exact Mass | 302.172943 |
| PSA | 78.90000 |
| LogP | 2.95 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.448 |
| InChIKey | UYXTWWCETRIEDR-UHFFFAOYSA-N |
| SMILES | CCCC(=O)OCC(COC(=O)CCC)OC(=O)CCC |
| Storage condition | Store at RT. |
| Stability | Stable. Incompatible with strong oxidizing agents. |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
|
~92%
butyrin CAS#:60-01-5 |
| Literature: Prager, Rolf H.; Yurui, Zhang Australian Journal of Chemistry, 1989 , vol. 42, # 6 p. 1003 - 1005 |
|
~95%
butyrin CAS#:60-01-5 |
| Literature: Akthelia Pharmaceuticals Patent: US2011/118217 A1, 2011 ; |
|
~%
butyrin CAS#:60-01-5 |
| Literature: Nudelman, Abraham; Ruse, Margaretta; Aviram, Adina; Rabizadeh, Ester; Shaklai, Matityahu; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 687 - 694 |
|
~%
butyrin CAS#:60-01-5 |
| Literature: Newman; Trikojus; Harker Journal and Proceedings of the Royal Society of New South Wales, vol. 59, p. 296 Chem. Zentralbl., 1927 , vol. 98, # II p. 802 |
|
~%
butyrin CAS#:60-01-5 |
| Literature: Partheil; v.Velsen Archiv der Pharmazie (Weinheim, Germany), 1900 , vol. 238, p. 267 |
|
~%
butyrin CAS#:60-01-5 |
| Literature: Newman; Trikojus; Harker Journal and Proceedings of the Royal Society of New South Wales, vol. 59, p. 298 Chem. Zentralbl., 1927 , vol. 98, # II p. 802 |
|
~%
butyrin CAS#:60-01-5 |
| Literature: Guth Z.B., 1903 , vol. 44, p. 95 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 7 | |
|---|---|
| DownStream 9 | |
CAS#:557-25-5
CAS#:30403-46-4
CAS#:17364-00-0
CAS#:623-42-7
CAS#:56149-03-2
CAS#:555-43-1
CAS#:66411-63-0
CAS#:139665-43-3This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2915900090 |
|---|---|
| Summary | 2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Solid lipid particles for oral delivery of peptide and protein drugs III - the effect of fed state conditions on the in vitro release and degradation of desmopressin.
AAPS J. 16(4) , 875-83, (2014) The effect of food intake on the release and degradation of peptide drugs from solid lipid particles is unknown and was therefore investigated in vitro using different fed state media in a lipolysis m... |
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Biochemistry of lipolytic enzymes secreted by Penicillium solitum and Cladosporium cladosporioides.
Biosci. Biotechnol. Biochem. 78(2) , 245-54, (2014) Two distinct extracellular lipases were obtained from Penicillium solitum 194A, isolated from domestic compost, and Cladosporium cladosporioides 194B, isolated from dairy wastewater. These alkaline en... |
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Candida rugosa lipase immobilization on hydrophilic charged gold nanoparticles as promising biocatalysts: Activity and stability investigations.
Colloids Surf. B Biointerfaces 131 , 93-101, (2015) In this work, a simple and versatile methodology to obtain two different bioconjugated systems has been developed by the immobilization of Candida rugosa lipase (CRL) on hydrophilic gold nanoparticles... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Tributyrinine |
| MFCD00009392 |
| 1,2,3-Propanetriyl tributanoate |
| Butanoic acid, 1,2,3-propanetriyl ester |
| Propane-1,2,3-triyl tributanoate |
| Tributyroin |
| glyceryl tributyrate |
| Tributin |
| Butyryl triglyceride |
| Glycerol tributyrate |
| 2,3-di(butanoyloxy)propyl butanoate |
| EINECS 200-451-5 |
| glycerol tributanoate |
| 1,2,3-Tributyrylglycerol |
| Butanoic acid,1,2,3-propanetriyl ester |
| butyrin |
| TRIBUTYRIN |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the LogP of tributyrin? |
| A: LogP of tributyrin is 2.95. |
| Q: What is the InChIKey of tributyrin? |
| A: InChIKey of tributyrin is UYXTWWCETRIEDR-UHFFFAOYSA-N. |
| Q: What are the downstream products of tributyrin? |
| A: Related downstream products(CAS) of tributyrin: 557-25-5;30403-46-4;17364-00-0;623-42-7;56-81-5;56149-03-2;555-43-1;66411-63-0;139665-43-3. |
| Q: What is the CAS number of tributyrin? |
| A: CAS number of tributyrin is 60-01-5. |
| Q: What are the storage conditions for tributyrin? |
| A: Storage conditions for tributyrin: Store at RT. |
| Q: What are the upstream materials of tributyrin? |
| A: Related upstream materials(CAS) of tributyrin: 56-81-5;107-92-6;106-31-0;144-55-8;156-54-7;96-11-7;5076-24-4. |
| Q: What is the polar surface area (PSA) of tributyrin? |
| A: Polar surface area (PSA) of tributyrin is 78.90000. |
| Q: What English synonyms does tributyrin have? |
| A: English synonyms of tributyrin: Tributyrinine, MFCD00009392, 1,2,3-Propanetriyl tributanoate, Butanoic acid, 1,2,3-propanetriyl ester, Propane-1,2,3-triyl tributanoate, Tributyroin, glyceryl tributyrate, Tributin, Butyryl triglyceride, Glycerol tributyrate, 2,3-di(butanoyloxy)propyl butanoate, EINECS 200-451-5, glycerol tributanoate, 1,2,3-Tributyrylglycerol, Butanoic acid,1,2,3-propanetriyl ester, butyrin, TRIBUTYRIN. |
| Q: What is the SMILES notation of tributyrin? |
| A: SMILES notation of tributyrin is CCCC(=O)OCC(COC(=O)CCC)OC(=O)CCC. |
| Q: What is the molecular formula of tributyrin? |
| A: Molecular formula of tributyrin is C15H26O6. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |
| Zhongshan Xingrui Chemical Co. , Ltd. |
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- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Palmitic acid
- Price: Check
- Purity: 98.0%
- Delivery: 10 Day
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- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Glyceryl tributyrate
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
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- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: Butanoic acid,1,2,3-propanetriyl ester
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Delivery: Inquiry
- Contact: Anson
- Email: info@tianfuchem.com
- Zhongshan Xingrui Chemical Co. , Ltd.
- China
- Product Name: butyrin
- Price: ￥Inquiry/25kg
- Purity: 99.0%
- Delivery: Inquiry
- Contact: Wang Jie
- Email: 3096638339@qq.com
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