508-99-6

508-99-6 structure

508-99-6 structure

Name: Hydrocortisone cypionate
Chemical Name: 17-Hydroxycorticosterone 21.β.-cyclopentylpropionate
CAS Number: 508-99-6
Molecular Formula: C₂₉H₄₂O₆
Molecular Weight: 486.64000
Catalog: Signaling Pathways GPCR/G Protein Glucocorticoid Receptor
Create Date: 2016-05-03 15:39:06
Modify Date: 2024-01-02 21:54:39
Hydrocortisone cypionate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester.

Name	17-Hydroxycorticosterone 21.β.-cyclopentylpropionate
Synonyms	Hydrocortisone cypionate

Description	Hydrocortisone cypionate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology
In Vitro	Hydrocortisone (50 nM) shows a dose-dependent down-regulation of GR transcript in hCMEC/D3 cells. Hydrocortisone supplementation of the serum-reduced cell differentiation medium leads to a significant increase in TER across the hCMEC/D3 monolayer[1]. Hydrocortisone-treated Dendritic cells (DCs) show a decreased expression of MHC II molecules, the costimulatory molecule CD86, and the DC-specific marker CD83, as well as a strongly reduced IL-12 secretion. Hydrocortisone-treated DCs inhibit production of IFN-γ but induce an increased release of IL-4 and no change in IL-5[2]. Hydrocortisone reduces postischemic oxidative stress, perfusion pressure, and transudate formation. Hydrocortisone inhibits postischemic shedding of syndecan-1, heparan sulfate, and hyaluronan as is release of histamine from resident mast cells[3].
References	[1]. F?rster C, et al. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008 Apr 1;586(7):1937-49. [2]. Bellinghausen I, et al. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol. 2001 Aug;108(2):242-9. [3]. Chappell D, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007 Nov;107(5):776-84.

Density	1.22g/cm3
Boiling Point	645ºC at 760mmHg
Molecular Formula	C₂₉H₄₂O₆
Molecular Weight	486.64000
Flash Point	208.4ºC
Exact Mass	486.29800
PSA	100.90000
LogP	4.30290
Index of Refraction	1.572
Storage condition	2-8℃

RIDADR	NONH for all modes of transport