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644-78-0

644-78-0 structure
644-78-0 structure
  • Name: 2-Hydroxychalcone
  • Chemical Name: 2-Hydroxychalcone
  • CAS Number: 644-78-0
  • Molecular Formula: C15H12O2
  • Molecular Weight: 224.25500
  • Catalog: Biochemical Plant extracts
  • Create Date: 2018-04-21 08:00:00
  • Modify Date: 2026-07-09 23:56:09
  • 2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3].
Name 2-Hydroxychalcone
Synonyms 3-(2-hydroxyphenyl)-1-phenyl-2-propen-1-one
2-(2-Hydroxybenzal)acetophenone 2-(2-Hydroxybenzylidene)acetophenone Salicylalacetophenone
3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one
MFCD00016449
2-HYDROXYBENZYLIDENE ACETOPHENONE
2-(2-HYDROXYBENZAL)ACETOPHENONE
2-Hydroxychalcone>
EINECS 211-422-1
2-Propen-1-one, 3-(2-hydroxyphenyl)-1-phenyl
3-(2-HYDROXY-PHENYL)-1-PHENYL-PROPENONE
2-HYDROXYCHALCONE(UNSPECIFIEDISOMER)
BENZYLIDENE-2-HYDROXYACETOPHENONE
(E)-3-(2-HYDROXYPHENYL)-1-PHENYLPROP-2-EN-1-ONE
TRANS-2-HYDROXYCHALCONE
inhibit,Inhibitor,Apoptosis,Nuclefactor-κB,Nuclefactor-kappaB,NF-κB,TNBC,2 Hydroxychalcone,2-Hydroxychalcone,Bcl-2 Family,2Hydroxychalcone
(2-Hydroxybenzylidene)acetophenone~3-(2-Hydroxyphenyl)-1-phenyl-2-propen-1-one
2-Hydroxychalcone, 10 mM in DMSO
SALICYLALACETOPHENONE
HYDROXYCHALCONE, 2
TRANS-2-HYDROXYBENZYLIDENEACETOPHENONE
2-(2-HYDROXYBENZYLIDENE)ACETOPHENONE
α-(o-Hydroxybenzylidene)acetophenone
2-HYDROXYCHALCONE
o-Hydroxychalcone
HYDROXYCHALCONE,2-(AS)
Description 2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3].
Related Catalog
In Vitro 2-Hydroxychalcone inhibits invasion of triple negative breast cancer cells[1]. 2-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner[2].
References

[1]. Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203(3):565-72.

[2]. B Madan, et al. 2'-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58(3):526-34.

[3]. BABITA MADAN, et al. 2-Hydroxychalcone Inhibits Nuclear Factor-kB and Blocks Tumor Necrosis Factor-a- and Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol 58:526–534, 2000.
Density 1.191g/cm3
Boiling Point 396.566ºC at 760 mmHg
Melting Point 144-150ºC(lit.)
Molecular Formula C15H12O2
Molecular Weight 224.25500
Flash Point 169.35ºC
Exact Mass 224.08400
PSA 37.30000
LogP 3.28830
Index of Refraction 1.654
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S36
WGK Germany 3
HS Code 2914501900
HS Code 2914501900
Summary 2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
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