Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 2-Hydroxychalcone
Price: ￥658.0/100mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: 2-Hydroxychalcone
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Propen-1-one,3-(2-hydroxyphenyl)-1-phenyl-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

644-78-0

644-78-0 structure

644-78-0 structure

Name: 2-Hydroxychalcone
Chemical Name: 2-Hydroxychalcone
CAS Number: 644-78-0
Molecular Formula: C₁₅H₁₂O₂
Molecular Weight: 224.25500
Catalog: Biochemical Plant extracts
Create Date: 2018-04-21 08:00:00
Modify Date: 2024-01-11 18:42:12
2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3].

Name	2-Hydroxychalcone
Synonyms	3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one EINECS 211-422-1 MFCD00016449

Description	2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Metabolic Disease
In Vitro	2-Hydroxychalcone inhibits invasion of triple negative breast cancer cells[1]. 2-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner[2].
References	[1]. Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203(3):565-72. [2]. B Madan, et al. 2'-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58(3):526-34. [3]. BABITA MADAN, et al. 2-Hydroxychalcone Inhibits Nuclear Factor-kB and Blocks Tumor Necrosis Factor-a- and Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol 58:526–534, 2000.

Density	1.191g/cm3
Boiling Point	396.566ºC at 760 mmHg
Melting Point	144-150ºC(lit.)
Molecular Formula	C₁₅H₁₂O₂
Molecular Weight	224.25500
Flash Point	169.35ºC
Exact Mass	224.08400
PSA	37.30000
LogP	3.28830
Index of Refraction	1.654

Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
WGK Germany	3
HS Code	2914501900

Precursor 9
90-02-8 98-86-2 89-95-2 13636-88-9
31487-82-8 100-52-7 582-24-1 5896-17-3
6272-41-9
DownStream 10
3516-95-8 487-26-3 1621-55-2 18732-50-8
70460-60-5 75630-71-6 67139-38-2 89406-21-3
4376-83-4 6274-71-1

HS Code	2914501900
Summary	2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%