2-Hydroxychalcone

Modify Date: 2025-08-25 18:44:12

2-Hydroxychalcone structure	Common Name	2-Hydroxychalcone
	CAS Number	644-78-0	Molecular Weight	224.25500
	Density	1.191g/cm3	Boiling Point	396.566ºC at 760 mmHg
	Molecular Formula	C₁₅H₁₂O₂	Melting Point	144-150ºC(lit.)
	MSDS	N/A	Flash Point	169.35ºC

Use of 2-Hydroxychalcone

2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3].

Name	2-Hydroxychalcone
Synonym	More Synonyms

Description	2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Metabolic Disease
In Vitro	2-Hydroxychalcone inhibits invasion of triple negative breast cancer cells[1]. 2-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner[2].
References	[1]. Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203(3):565-72. [2]. B Madan, et al. 2'-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58(3):526-34. [3]. BABITA MADAN, et al. 2-Hydroxychalcone Inhibits Nuclear Factor-kB and Blocks Tumor Necrosis Factor-a- and Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol 58:526–534, 2000.

Density	1.191g/cm3
Boiling Point	396.566ºC at 760 mmHg
Melting Point	144-150ºC(lit.)
Molecular Formula	C₁₅H₁₂O₂
Molecular Weight	224.25500
Flash Point	169.35ºC
Exact Mass	224.08400
PSA	37.30000
LogP	3.28830
Index of Refraction	1.654

2-Hydroxychalcone MSDS(Chinese)

Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
WGK Germany	3
HS Code	2914501900

Precursor 9
CAS#:90-02-8 Salicylaldehyde CAS#:98-86-2 Acetophenone CAS#:89-95-2 2-Methylbenzyl ... CAS#:13636-88-9 2-Propen-1-one,...
CAS#:31487-82-8 1-[2-(BENZYLOXY... CAS#:100-52-7 Benzaldehyde CAS#:582-24-1 Glycolophenone CAS#:5896-17-3 2-(Benzyloxy)be...
CAS#:6272-41-9 2-Phenylbenzopy...
DownStream 10
CAS#:3516-95-8 2'-Hydroxy-3-ph... CAS#:487-26-3 FLAVANONE CAS#:1621-55-2 3-Hydroxy-2-phe... CAS#:18732-50-8 6-(5-phenyl-1,2...
CAS#:70460-60-5 2-Phenyl-2H-chr... CAS#:75630-71-6 (5,7-DIBROMO-1-... CAS#:67139-38-2 6-(3-phenyl-2H-... CAS#:89406-21-3 2-(4-phenyl-2,3...
CAS#:4376-83-4 3-(2-Hydroxyphe... CAS#:6274-71-1 2,4-diphenylchr...

HS Code	2914501900
Summary	2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one

EINECS 211-422-1

MFCD00016449

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

2-Hydroxychalcone

Use of 2-Hydroxychalcone

Names

2-Hydroxychalcone Biological Activity

Chemical & Physical Properties

MSDS

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.