3367-88-2

3367-88-2 structure

Name: 3-(pyridin-2-ylmethylidene)-1H-indol-2-one
Chemical Name: (3E)-3-(pyridin-2-ylmethylidene)-1H-indol-2-one
CAS Number: 3367-88-2
Molecular Formula: C₁₄H₁₀N₂O
Molecular Weight: 222.24200
Catalog: Signaling Pathways PI3K/Akt/mTOR GSK-3
Create Date: 2017-03-03 06:19:44
Modify Date: 2024-01-08 13:44:22
(E/Z)-GSK-3β inhibitor 1 is a racemic compound of (E)-GSK-3β inhibitor 1 and (Z)-GSK-3β inhibitor 1 isomers. GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM[1].

Name	(3E)-3-(pyridin-2-ylmethylidene)-1H-indol-2-one

Description	(E/Z)-GSK-3β inhibitor 1 is a racemic compound of (E)-GSK-3β inhibitor 1 and (Z)-GSK-3β inhibitor 1 isomers. GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Research Areas >> Metabolic Disease Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
References	[1]. Lozinskaya NA, et al. Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors. Bioorg Med Chem. 2019 May 1;27(9):1804-1817.

Hazard Codes	Xi
HS Code	2933790090

HS Code	2933790090
Summary	2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%