48236-96-0

48236-96-0 structure

Name: 3",8"-Binaringenin
Chemical Name: (2S)-8-{5-[(2S)-5,7-Dihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl]- 2-hydroxyphenyl}-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H -chromen-4-one
CAS Number: 48236-96-0
Molecular Formula: C₃₀H₂₂O₁₀
Molecular Weight: 542.490
Catalog: Natural product Flavonoids
Create Date: 2016-10-21 13:26:11
Modify Date: 2024-01-04 18:18:17
Tetrahydroamentoflavone (Amentoflavanone) is a potent xanthine oxidase (XO) inhibitor. Tetrahydroamentoflavone has inhibitory activity for XO with IC50 and Ki values of 92 nM and 0.982 μM, respectively. Tetrahydroamentoflavone can be used for the research of inflammatory disorders and gout[1].

Name	(2S)-8-{5-[(2S)-5,7-Dihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl]- 2-hydroxyphenyl}-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H -chromen-4-one
Synonyms	8-[5-(5,7-Dihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one 3",8"-Binaringenin 4H-1-Benzopyran-4-one, 8-[5-(3,4-dihydro-5,7-dihydroxy-4-oxo-2H-1-benzopyran-2-yl)-2-hydroxyphenyl]-2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-

Description	Tetrahydroamentoflavone (Amentoflavanone) is a potent xanthine oxidase (XO) inhibitor. Tetrahydroamentoflavone has inhibitory activity for XO with IC50 and Ki values of 92 nM and 0.982 μM, respectively. Tetrahydroamentoflavone can be used for the research of inflammatory disorders and gout[1].
Related Catalog	Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase
Target	IC50: 92 nM (XO)[1]. Ki: 0.982 μM (XO)[1].
In Vitro	Tetrahydroamentoflavone 对 XO 具有抑制活性，IC50 和 Ki 值分别为 92 nM 和 0.982 μM[1]。
References	[1]. Ranjith Arimboor, et al. Tetrahydroamentoflavone (THA) from Semecarpus anacardium as a potent inhibitor of xanthine oxidase. J Ethnopharmacol. 2011 Feb 16;133(3):1117-20.

Hazard Codes	Xi

Precursor 0
DownStream 2
1617-53-4 34340-51-7