38230-32-9
38230-32-9 structure
- Name: dehydrocurdione
- Chemical Name: (6Z,10S)-3-Isopropylidene-6,10-dimethyl-6-cyclodecene-1,4-dione
- CAS Number: 38230-32-9
- Molecular Formula: C15H22O2
- Molecular Weight: 234.33400
- Catalog: Signaling Pathways NF-κB Keap1-Nrf2
- Create Date: 2018-06-24 12:55:10
- Modify Date: 2025-08-20 16:56:32
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Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity[1][2].
| Name | (6Z,10S)-3-Isopropylidene-6,10-dimethyl-6-cyclodecene-1,4-dione |
|---|---|
| Synonyms | MFCD03792779 |
| Description | Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity[1][2]. |
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| Related Catalog | |
| In Vitro | Dehydrocurdione (RAW 264.7 cells) concentration-dependently increases the HO-1 mRNA level for 3 hr and the protein level for 6 hr, and both effects reached significance at a concentration of 100 μM[1]. Dehydrocurdione interacts with Keap, resulting in Nrf2 translocation followed by activation ofthe HO-1 E2 enhancer[1]. Western Blot Analysis[1] Cell Line: RAW 264.7 cells Concentration: 100 μM Incubation Time: 24 hours Result: Transiently increased the HO-1 protein level, and its effect peaked at 3-6 hr. |
| In Vivo | Dehydrocurdione (P.o ;120 mg/kg, daily for 12 days) significantly reduces chronic adjuvant arthritis[2]. Dehydrocurdione (200 mg/kg; p.o.; Sprague-Dawley rats) dose-dependently inhibits carrageenan-induced paw edema[2]. Animal Model: Wistar rats[2] Dosage: 120 mg/kg Administration: P.o ; daily for 12 days Result: Significantly reduces chronic adjuvant arthritis. |
| References |
| Density | 0.962g/cm3 |
|---|---|
| Boiling Point | 362.9ºC at 760 mmHg |
| Molecular Formula | C15H22O2 |
| Molecular Weight | 234.33400 |
| Flash Point | 136.2ºC |
| Exact Mass | 234.16200 |
| PSA | 34.14000 |
| LogP | 3.61740 |
| Index of Refraction | 1.477 |