Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5,7-Dihydroxy-6-(3-methyl-2-butenyl)-8-(3-methylbutyryl)-4-phenyl-2H-1-benzopyran-2-one
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Purity: 98.0%
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5224-54-4

5224-54-4 structure

Name: 5,7-Dihydroxy-6-(3-methyl-2-butenyl)-8-(3-methylbutyryl)-4-phenyl-2H-1-benzopyran-2-one
Chemical Name: 5,7-dihydroxy-8-(3-methylbutanoyl)-6-(3-methylbut-2-enyl)-4-phenylchromen-2-one
CAS Number: 5224-54-4
Molecular Formula: C₂₅H₂₆O₅
Molecular Weight: 406.47100
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-02-21 05:37:59
Modify Date: 2025-09-15 11:30:37
Mammea A/BA has potent activity against Trypanosoma cruzi (T. cruzi). Mammea A/BA induces mitochondrial dysfunction, ROS production and DNA fragmentation, and increases number of acidic vacuoles. Mammea A/BA can induce apoptosis, autophagy and necrosis. Mammea A/BA can be used for researching chagas disease[1].

Name	5,7-dihydroxy-8-(3-methylbutanoyl)-6-(3-methylbut-2-enyl)-4-phenylchromen-2-one
Synonyms	Mammea A/BA isomammeisin

Description	Mammea A/BA has potent activity against Trypanosoma cruzi (T. cruzi). Mammea A/BA induces mitochondrial dysfunction, ROS production and DNA fragmentation, and increases number of acidic vacuoles. Mammea A/BA can induce apoptosis, autophagy and necrosis. Mammea A/BA can be used for researching chagas disease[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Infection Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS Signaling Pathways >> Autophagy >> Autophagy
Target	T. cruzi[1]
References	[1]. Rodríguez-Hernández KD, et al. Mammea type coumarins isolated from Calophyllum brasiliense induced apoptotic cell death of Trypanosoma cruzi through mitochondrial dysfunction, ROS production and cell cycle alterations. Bioorg Chem. 2020 Jul;100:103894.

98192-64-4

870-63-3

5224-54-4

Literature: Crombie; Jones; Palmer Tetrahedron Letters, 1985 , vol. 26, # 24 p. 2929 - 2932