5224-54-4

• 常用中文名：5,7-Dihydroxy-6-(3-methyl-2-butenyl)-8-(3-methylbutyryl)-4-phenyl-2H-1-benzopyran-2-one
• 常用英文名：5,7-Dihydroxy-6-(3-methyl-2-butenyl)-8-(3-methylbutyryl)-4-phenyl-2H-1-benzopyran-2-one
• CAS号：5224-54-4
• 分子式：C₂₅H₂₆O₅
• 分子量：406.47100
• 相关类别： 信号通路 细胞凋亡 细胞凋亡
• 发布时间：2017-02-21 05:37:59
• 更新时间：2024-01-05 12:52:36
• Mammea A/BA对克氏锥虫(T.cruzi)有较强的活性。Mammea A/BA诱导线粒体功能障碍、ROS产生和DNA断裂,并增加酸性空泡的数量。Mammea-A/BA可诱导细胞凋亡、自噬和坏死。Mammea A/BA可用于研究恰加斯病[1]。

名称

• 英文名: 5,7-dihydroxy-8-(3-methylbutanoyl)-6-(3-methylbut-2-enyl)-4-phenylchromen-2-one
• 英文别名: Mammea A/BA; isomammeisin

物化性质

• 密度: 1.219g/cm3
• 沸点: 629.1ºC at 760 mmHg
• 分子式: C₂₅H₂₆O₅
• 分子量: 406.47100
• 闪点: 215.3ºC
• 精确质量: 406.17800
• PSA: 87.74000
• LogP: 5.60870
• 折射率: 1.607

生物活性

• 描述: Mammea A/BA对克氏锥虫(T.cruzi)有较强的活性。Mammea A/BA诱导线粒体功能障碍、ROS产生和DNA断裂,并增加酸性空泡的数量。Mammea-A/BA可诱导细胞凋亡、自噬和坏死。Mammea A/BA可用于研究恰加斯病[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 感染
  信号通路 >> 蛋白酪氨酸激酶 >> ROS
  信号通路 >> 自噬 >> 自噬
• 靶点:

  T. cruzi[1]

• 参考文献:

  [1]. Rodríguez-Hernández KD, et al. Mammea type coumarins isolated from Calophyllum brasiliense induced apoptotic cell death of Trypanosoma cruzi through mitochondrial dysfunction, ROS production and cell cycle alterations. Bioorg Chem. 2020 Jul;100:103894.

合成路线

98192-64-4 870-63-3 ~% 5224-54-4

文献：Crombie; Jones; Palmer Tetrahedron Letters, 1985 , vol. 26, # 24 p. 2929 - 2932

108-73-6 ~% 5224-54-4

文献：Crombie, Leslie; Jones, Raymond C. F.; Palmer, Christopher J. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 317 - 332

26103-97-9 ~% 5224-54-4

文献：Crombie, Leslie; Jones, Raymond C. F.; Palmer, Christopher J. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 317 - 332

108-12-3 ~% 5224-54-4

文献：Crombie, Leslie; Jones, Raymond C. F.; Palmer, Christopher J. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 317 - 332

98192-64-4 503-60-6 ~22% 5224-54-4

文献：Crombie, Leslie; Jones, Raymond C. F.; Palmer, Christopher J. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 317 - 332

94-02-0 ~% 5224-54-4

文献：Crombie, Leslie; Jones, Raymond C. F.; Palmer, Christopher J. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 317 - 332

98-86-2 ~% 5224-54-4

文献：Crombie, Leslie; Jones, Raymond C. F.; Palmer, Christopher J. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 317 - 332

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