Henan Tianfu Chemical Co., Ltd.
China
Product Name: ADAPALENE
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson
Email: info@tianfuchem.com

106685-40-9

106685-40-9 structure

Name: Adapalene
Chemical Name: adapalene
CAS Number: 106685-40-9
Molecular Formula: C₂₈H₂₈O₃
Molecular Weight: 412.520
Catalog: API Special medicine Dermatology medication
Create Date: 2018-07-30 12:11:16
Modify Date: 2026-06-30 12:53:39
Adapalene(CD-271; Differin), a synthetic retinoid, is a retinoic acid receptor agonist (RAR).Target: Retinoic acid receptor agonist (RAR)Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. Adapalene is possibly more effective than tretinoin 0.025% gel in the treatment of acne vulgaris [1].Thirty-six rats of either sex were divided into six groups (two control groups, and an etodolac, indomethacin, tretinoin and adapalene group) of six animals each. Each group was given different drugs or chemicals. The inhibitory activities of the drugs were determined on carrageenan-induced rat-paw oedema. The inhibition rate (53.48%) in the tretinoin group was found to be higher thanadapalene and controls (P < 0.05). Adapalene was found to have an inhibition rate of 10.28%, and when compared with the other groups, was found to have no statistically significant anti-inflammatory activity [2].

Name	adapalene
Synonyms	Adapalene > 6-[4-Methoxy-3-(adamantan-1-yl)phenyl]-2-naphthalenecboxylic acid Adapalene for peak identification CRS CD-271 Monoclonal Anti-NGFR antibody produced in mouse Adapalene //BP Adapalenum Adapalene CRS Adapin 6-[3-(1-ADAMANTYL)-4-METHOXYPHENYL]-2-NAPHTHALENE CBOXYLIC ACID 6-[3-(Adamantan-1-yl)-4-methoxyphenyl]-2-naphthoic acid Adapalone Adapaleno Adaferin Adapalene, 10 mM in DMSO Differine Ada palin Adapalene-13C6 Adapalene Base 6-[3-(1-adamantyl)-4-methoxy-phenyl]naphthalene-2-cboxylic acid Adapalene, >= [1]6-[4-Methoxy-3-(tricyclo[3.3.,7~]dec-1-yl)phenyl]naphthalene-2-cboxylic acid Adapalene - Bio-X 6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecboxylic Acid Adapalene - - Calbiochem Differin 6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic Acid 6-[3-(adaMantan-1-yl)-4-Methoxyphenyl]naphthalene-2-cboxylic acid 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid Adapalene (superfine) ADAPALENE-API 6-(3-(AdaMantan-1-yl)-4-Methoxyphenyl)-2-naphthoic acid 6-[3-(1-ADAMANTYL)-4-METHOXYPHENYL]-2-NAPHTHOIC ACID p75(NTR) 2-Naphthalenecboxylic acid, 6-(4-methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl) Differi MFCD03106112 AdapaleneQ: What is Adapalene Q: What is the CAS Number of Adapalene Q: What is the storage condition of Adapalene Q: What e the applications of Adapalene 6-(4-methoxy-3-tricyclo[3.3.1.1]dec-1-ylphenyl)naphthalene-2-carboxylic acid 6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid Adapalene-d6 6-[4-methoxy-3-(tricyclo[3.3.1.1]dec-1-yl)phenyl]naphthalene-2-carboxylic acid Adapalen ADAPALENE

Description	Adapalene(CD-271; Differin), a synthetic retinoid, is a retinoic acid receptor agonist (RAR).Target: Retinoic acid receptor agonist (RAR)Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. Adapalene is possibly more effective than tretinoin 0.025% gel in the treatment of acne vulgaris [1].Thirty-six rats of either sex were divided into six groups (two control groups, and an etodolac, indomethacin, tretinoin and adapalene group) of six animals each. Each group was given different drugs or chemicals. The inhibitory activities of the drugs were determined on carrageenan-induced rat-paw oedema. The inhibition rate (53.48%) in the tretinoin group was found to be higher thanadapalene and controls (P < 0.05). Adapalene was found to have an inhibition rate of 10.28%, and when compared with the other groups, was found to have no statistically significant anti-inflammatory activity [2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR Research Areas >> Inflammation/Immunology
References	[1]. Ellis CN, et al. Comparison of adapalene 0.1% solution and tretinoin 0.025% gel in the topical treatment of acne vulgaris. Br J Dermatol. 1998 Oct;139 Suppl 52:41-7. [2]. Akdeniz N, et al. Anti-inflammatory effects of tretinoin (all-trans-retinoic acid) 0.1% and adapalene 0.1% in rats. Clin Exp Dermatol. 2005 Sep;30(5):570-2.

Density	1.2±0.1 g/cm3
Boiling Point	606.3±55.0 °C at 760 mmHg
Melting Point	319-322ºC
Molecular Formula	C₂₈H₂₈O₃
Molecular Weight	412.520
Flash Point	205.9±25.0 °C
Exact Mass	412.203857
PSA	46.53000
LogP	8.04
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.655
Storage condition	Store at +4°C

Hazard Statements	H413
RIDADR	NONH for all modes of transport
HS Code	2918990090

Precursor 10
951645-46-8 459423-32-6 5773-80-8 106685-41-0
124-38-9 104224-68-2 768-95-6 104224-63-7
106-41-2 33626-98-1
DownStream 0

HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

1993188-94-5	1416438-54-4
189756-76-1	1394731-28-2
1795458-24-0	1795472-39-7
1795442-45-3	1795455-64-9
1798463-32-7	1798511-32-6