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30827-99-7

30827-99-7 structure
30827-99-7 structure
  • Name: AEBSF HCl
  • Chemical Name: 4-(2-aminoethyl)benzenesulfonyl fluoride,hydrochloride
  • CAS Number: 30827-99-7
  • Molecular Formula: C8H11ClFNO2S
  • Molecular Weight: 239.695
  • Catalog: Chemical reagent Organic reagent Sulfonyl halide
  • Create Date: 2018-11-25 20:26:32
  • Modify Date: 2024-01-02 10:21:18
  • AEBSF is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin.
Name 4-(2-aminoethyl)benzenesulfonyl fluoride,hydrochloride
Synonyms 4-(2-Aminoethyl)benzene-1-sulfonyl fluoride hydrochloride
Benzenesulfonyl fluoride, 4-(2-aminoethyl)-, hydrochloride (1:1)
4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride
2-[4-(fluorosulfonyl)phenyl]ethanaminium chloride
AEBSF
AEBSF hydrochloride
4-(2-Aminoethyl)benzenesulphonyl fluoride hydrochloride
4-(2-Aminoethyl)benzenesulfonyl fluoride, hydrochloride
MFCD00132962
Pefabloc SC
4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride (1:1)
Benzenesulfonyl fluoride hydrochloride, 4-(2-aminoethyl)-
4-(2-Aminoethyl)-benzenesulfonylfluoride hydrochloride
AEBSF HCl
Description AEBSF is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin.
Related Catalog
In Vitro AEBSF inhibits the constitutive production of Aβ by directly inhibiting β-secretase in five different human cell lines, both neural and nonneural[1]. AEBSF, as a serine protease inhibitor, inhibits the lysis of leukemic cells by human macrophages without inhibiting macrophage secretion of TNF-α and IL-1β[2]. AEBSF also disturbs the growth of blastocysts on endometrial cells and inhibit the adhesion of HeLa cells on HUVECs by altering the protein secretion pattern[4].
In Vivo AEBSF (76.8 mg/kg daily, i.p.) results in prolongation of the survival of mice that have been given a lethal T. gondii infection[3]. AEBSF also reduces airway response and underlying inflammation in cockroach allergen-induced murine model[4].
Cell Assay The HeLa cells suspended in RPMI-1640 media containing 10% FCS are plated into each well of a 96-well microplate (5×103 cells/200 μL/well). After incubation for 24 h at 37°C, cells are treated with different doses of AEBSF (0, 25, 50, 100 μg/mL) for 48 h. Then, 20 μL fresh 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-diphenytetrazoliumromide (MTT) reagent (5 μg/μL) is added into each well, and cells are cultured at 37°C in 5% CO2 for another 4 h. The media are discarded carefully, and 150 μL DMSO is added. Absorbance is read on a microplate reader at dual wavelengths of 540 and 620 nm.
Animal Admin Mice injected with 2.5×103 parasites are randomLy assigned to one of the treatment groups according to the treatment given: without drugs (control group), vehicle alone (vehicle control group), pyrimethamine alone at different doses, LY311727 alone at different doses, AEBSF alone at different doses or AEBSF 76.8 mg/kg plus pyrimethamine 10 mg/kg. Each treatment group consists of 10 animals. Treatment is initiated 24 h after parasite inoculation and is continued for seven consecutive days. Mouse survival is monitored daily and continued in live mice until 15 days post-infection. All experiments are performed three times and the data shown represent the cumulative results.
References

[1]. Citron M, et al. Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF. Neuron. 1996 Jul;17(1):171-9

[2]. Nakabo Y, et al. Lysis of leukemic cells by human macrophages: inhibition by 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor. J Leukoc Biol. 1996 Sep;60(3):328-36.

[3]. Buitrago-Rey R, et al. Evaluation of two inhibitors of invasion: LY311727 [3-(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy)propane phosphonic acid] and AEBSF [4-(2-aminoethyl)-benzenesulphonyl fluoride] in acute murine toxoplasmosis. J Antimicrob Chemother.

[4]. Jiang YH, et al. Serine protease inhibitor 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) inhibits the rat embryo implantation in vivo and interferes with cell adhesion in vitro. Contraception. 2011 Dec;84(6):642-8.
Boiling Point 292.5ºC at 760 mmHg
Melting Point 175-177 °C
Molecular Formula C8H11ClFNO2S
Molecular Weight 239.695
Flash Point 130.7ºC
Exact Mass 239.018311
PSA 68.54000
LogP 3.42910
Storage condition 0-6°C
Water Solubility 10 g/L (20 ºC)
Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H314
Precautionary Statements P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes C:Corrosive;
Risk Phrases R34
Safety Phrases S45-S36/37/39-S26
RIDADR UN 3261
Packaging Group II
Hazard Class 8
HS Code 2921499090
HS Code 2921499090
Summary 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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