181225-33-2

181225-33-2 structure

Name: Ginsenoside F4
Chemical Name: β-D-Glucopyranoside, (3β,6α,12β,20E)-3,12-dihydroxydammara-20(22),24-dien-6-yl 2-O-(6-deoxy-α-L-mannopyranosyl)
CAS Number: 181225-33-2
Molecular Formula: C₄₂H₇₀O₁₂
Molecular Weight: 766.998
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-02-07 08:00:00
Modify Date: 2024-01-12 00:00:04
Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis[1].Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues[2].

Name	β-D-Glucopyranoside, (3β,6α,12β,20E)-3,12-dihydroxydammara-20(22),24-dien-6-yl 2-O-(6-deoxy-α-L-mannopyranosyl)
Synonyms	β-D-ribo-Hexopyranoside, (3β,6α,12β,20E)-3,12-dihydroxydammara-20(22),24-dien-6-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-, (3ξ)- (3β,6α,12β,20E)-3,12-Dihydroxydammara-20(22),24-dien-6-yl (3ξ)-2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-ribo-hexopyranoside ginsenoside F4 (20E)-Ginsenoside F4

Description	Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis[1].Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
References	[1]. Chen B, et al. The apoptosis-inducing effect of ginsenoside F4 from steamed notoginseng on human lymphocytoma JK cells. Nat Prod Res. 2013;27(24):2351-4. [2]. Lee JH, et al. Ginsenosides from Korean red ginseng inhibit matrix metalloproteinase-13 expression in articular chondrocytes and prevent cartilage degradation. Eur J Pharmacol. 2014 Feb 5;724:145-51.