Shanghai Nianxing Industrial Co., Ltd
China
Product Name: PACOCF3
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

DC Chemicals Limited
China
Product Name: PACOCF3
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

141022-99-3

141022-99-3 structure

141022-99-3 structure

Name: PACOCF3
Chemical Name: Palmityl trifluoromethyl ketone
CAS Number: 141022-99-3
Molecular Formula: C₁₇H₃₁F₃O
Molecular Weight: 308.423
Create Date: 2018-07-30 01:32:14
Modify Date: 2024-01-27 07:01:36
PACOCF3 (Palmityltrifluoromethylketone) is a selective phospholipase A2 inhibitor with an IC50 of 3.8 μM. PACOCF3 alters Ca2+ signaling in renal tubular cells[1][2].

Name	Palmityl trifluoromethyl ketone
Synonyms	2-Heptadecanone, 1,1,1-trifluoro- MFCD00797669 1,1,1-Trifluoro-2-heptadecanone 1,1,1-trifluoroheptadecan-2-one PACOCF3 Pentadecyl trifluoromethyl ketone

Description	PACOCF3 (Palmityltrifluoromethylketone) is a selective phospholipase A2 inhibitor with an IC50 of 3.8 μM. PACOCF3 alters Ca2+ signaling in renal tubular cells[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase Research Areas >> Inflammation/Immunology
Target	PLA2:3.8 μM (IC50)
In Vitro	At a concentration of 20 μM, PACOCF3 does not change basal cytosolic free calcium concentrations ([Ca2+]i), but at concentrations of 50-250 μM PACOCF3 induced an increase in [Ca2+]i by activating extracellular Ca2+ entry which is partly suppressed by 50 μM La3+[2]. The effect of PACOCF3 is abolished by removal of extracellular Ca2+. PACOCF3 (10 μM) enhances both the peak value and the area under the curve of the [Ca2+]i increase induced by 10 μM ATP and 1 μM bradykinin by potentiating extracellular Ca2+ influx without affecting internal Ca2+ release[2].
References	[1]. E J Ackermann, et al. Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J Biol Chem. 1995 Jan 6;270(1):445-50. [2]. C R Jan, et al. Dual action of palmitoyl trifluoromethyl ketone (PACOCF3) on Ca2+ signaling: activation of extracellular Ca2+ influx and alteration of ATP- and bradykinin-induced Ca2+ responses in Madin Darby canine kidney cells. Arch Toxicol. 2000 Oct;74(8):447-51.

Density	1.0±0.1 g/cm3
Boiling Point	329.0±37.0 °C at 760 mmHg
Molecular Formula	C₁₇H₃₁F₃O
Molecular Weight	308.423
Flash Point	227.1±18.0 °C
Exact Mass	308.232697
PSA	17.07000
LogP	7.93
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.418
Storage condition	-20°C

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H225-H319
Precautionary Statements	P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26
RIDADR	UN1170 - class 3 - PG 2 - Ethanol, solution