Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4alpha-Phorbol12,13-didecanoatesolid
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: 4alpha-PDD
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

27536-56-7

27536-56-7 structure

27536-56-7 structure

Name: 4alpha-PDD
Chemical Name: 4alpha-phorbol 12,13-didecanoate
CAS Number: 27536-56-7
Molecular Formula: C₄₀H₆₄O₈
Molecular Weight: 672.93100
Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
Create Date: 2017-05-20 02:51:51
Modify Date: 2024-01-03 19:12:48
4α-Phorbol 12,13-didecanoate (4αPDD) is a TRPV4 agonist with antidipsogenic effects. 4α-Phorbol 12,13-didecanoate promotes Ca2+ influx[1].

Name	4alpha-phorbol 12,13-didecanoate
Synonyms	4a-phorbol 12,13-didecanoate Phorbol-9,9a-didecanoat 4a-phenyl-4,4a,5,6,7,8-hexahydro-2H-cinnolin-3-one

Description	4α-Phorbol 12,13-didecanoate (4αPDD) is a TRPV4 agonist with antidipsogenic effects. 4α-Phorbol 12,13-didecanoate promotes Ca2+ influx[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
References	[1]. Hiromi Tsushima, et al. Antidipsogenic effects of a TRPV4 agonist, 4alpha-phorbol 12,13-didecanoate, injected into the cerebroventricle. Am J Physiol Regul Integr Comp Physiol. 2006 Jun;290(6):R1736-41. [2]. Lori Birder, et al. Activation of urothelial transient receptor potential vanilloid 4 by 4alpha-phorbol 12,13-didecanoate contributes to altered bladder reflexes in the rat. J Pharmacol Exp Ther. 2007 Oct;323(1):227-35.

Density	1.14g/cm3
Boiling Point	734.2ºC at 760mmHg
Molecular Formula	C₄₀H₆₄O₈
Molecular Weight	672.93100
Flash Point	212.4ºC
Exact Mass	672.46000
PSA	130.36000
LogP	7.31330
Vapour Pressure	6.92E-25mmHg at 25°C
Index of Refraction	1.546
Storage condition	-20°C

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H300 + H310 + H330-H334-H351
Precautionary Statements	P260-P264-P280-P284-P301 + P310-P302 + P350
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T+: Very toxic;
Risk Phrases	26/27/28-40-43
Safety Phrases	36/37/39-45
RIDADR	UN 2811 6.1/PG 2
Packaging Group	III
Hazard Class	6.1(b)

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