330829-30-6
330829-30-6 structure
- Name: MRT-10
- Chemical Name: N-[(3-benzamidophenyl)carbamothioyl]-3,4,5-trimethoxybenzamide
- CAS Number: 330829-30-6
- Molecular Formula: C24H23N3O5S
- Molecular Weight: 465.52200
- Catalog: Signaling Pathways Stem Cell/Wnt Smo
- Create Date: 2016-06-15 15:55:17
- Modify Date: 2024-01-28 02:02:50
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MRT-10 is a seven-transmembrane receptor smoothened (Smo) antagonist with an IC50 of 0.65 μM in the micromolar range in various Hedgehog (Hh) assays. MRT-10 binds to the Smo receptor at the level of the Bodipycyclopamine binding site. MRT-10 can be used for the research of cancer[1][2].
| Name | N-[(3-benzamidophenyl)carbamothioyl]-3,4,5-trimethoxybenzamide |
|---|---|
| Synonyms |
N-[[[3-(benzoylamino)phenyl]amino]thioxomethyl]-3,4,5-methoxy-benzamide
Immethridine dihydrobromide MRT-10 N-(3-benzamidophenylcarbamothioyl)-3,4,5-trimethoxybenzamide |
| Description | MRT-10 is a seven-transmembrane receptor smoothened (Smo) antagonist with an IC50 of 0.65 μM in the micromolar range in various Hedgehog (Hh) assays. MRT-10 binds to the Smo receptor at the level of the Bodipycyclopamine binding site. MRT-10 can be used for the research of cancer[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | MRT-10 inhibits the Smo-induced IP accumulation in a dosedependent manner (IC50=2.5 μM) in HEK293 cells[1]. MRT-10 (10-9-10-5 M; 2 h) blocks Bodipy-cyclopamine (5 nM; 2 h) binding to cells expressing mouse Smo in a dosedependent manner with an IC50=0.5 μM[1]. MRT-10 (10-9-10-5 M; 40 h) inhibits ShhN signaling in Shh-light2 cells in a dose-dependent manner with an IC50=0.64 μM[1]. MRT-10 (10-9-10-5 M; 6 days) inhibits the SAG-induced (0.1 μM) alkaline phosphatase (AP) activity with an IC50=0.90 μM ) in C3H10T1/2 cells[1]. |
| References |
| Molecular Formula | C24H23N3O5S |
|---|---|
| Molecular Weight | 465.52200 |
| Exact Mass | 465.13600 |
| PSA | 144.03000 |
| LogP | 5.27080 |
| Symbol |
GHS05, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H318-H410 |
| Precautionary Statements | P273-P280-P305 + P351 + P338-P501 |
| RIDADR | UN 3077 9 / PGIII |
