99217-68-2
99217-68-2 structure
- Name: Broussochalcone A
- Chemical Name: (E)-1-[2,4-dihydroxy-5-(3-methylbut-2-enyl)phenyl]-3-(3,4-dihydroxyphenyl)prop-2-en-1-one
- CAS Number: 99217-68-2
- Molecular Formula: C20H20O5
- Molecular Weight: 340.37000
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2016-02-16 04:01:43
- Modify Date: 2024-04-05 17:19:59
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Broussochalcone A is an antioxidant and an inhibitor of Xanthine Oxidase (IC50=2.21 μM), with free radical scavenging activity. Broussochalcone A inhibits iron-induced lipid peroxidation and nitric oxide synthesis in lipopolysaccharide (LPS) -activated macrophages. Broussochalcone A also induces Apoptosis of human renal carcinoma cells by increasing ROS levels and activating FOXO3 signaling pathways[1][2].
| Name | (E)-1-[2,4-dihydroxy-5-(3-methylbut-2-enyl)phenyl]-3-(3,4-dihydroxyphenyl)prop-2-en-1-one |
|---|---|
| Synonyms |
2-Propen-1-one,1-(2,4-dihydroxy-5-(3-methyl-2-butenyl)phenyl)-3-(3,4-dihydroxyphenyl)-,(E)
Broussochalcone A |
| Description | Broussochalcone A is an antioxidant and an inhibitor of Xanthine Oxidase (IC50=2.21 μM), with free radical scavenging activity. Broussochalcone A inhibits iron-induced lipid peroxidation and nitric oxide synthesis in lipopolysaccharide (LPS) -activated macrophages. Broussochalcone A also induces Apoptosis of human renal carcinoma cells by increasing ROS levels and activating FOXO3 signaling pathways[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Broussochalcone A (0.3, 1, and 3 μM; 10 min, 再 Fe 诱导 30 min) 在大鼠脑匀浆中抑制 Fe2+ (200 μM) 诱导的脂质过氧化[1]。 Broussochalcone A (1-30 μM; 30 min) 剂量依赖性增加 DPPH (100 μM) 的清除活性[1]。 Broussochalcone A (0.1-1 μM) 抑制细胞色素 c 还原，IC50 为 0.5 μM，这主要是由于其清除超氧阴离子活性，部分是由于其抑制黄嘌呤氧化酶活性[1]。 Broussochalcone A (1-20 μM; 24 h) 抑制亚硝酸盐的产生和 iNOS 蛋白的表达[1]。 Western Blot Analysis[1] Cell Line: LPS-activated RAW 264.7 macrophages Concentration: 1 μM, 3 μM, 10 μM, 20 μM Incubation Time: 30 min; then stimulated by LPS (1 μg/mL) for another 24 hr Result: Caused inhibition of iNOS protein expression dose-dependently. Inhibited IkBα phosphorylation. |
| References |
| Density | 1.312g/cm3 |
|---|---|
| Boiling Point | 595ºC at 760 mmHg |
| Molecular Formula | C20H20O5 |
| Molecular Weight | 340.37000 |
| Flash Point | 327.7ºC |
| Exact Mass | 340.13100 |
| PSA | 97.99000 |
| LogP | 3.91380 |
| Index of Refraction | 1.679 |