Broussochalcone A

Modify Date: 2024-04-05 17:19:59

Broussochalcone A Structure
Broussochalcone A structure
Common Name Broussochalcone A
CAS Number 99217-68-2 Molecular Weight 340.37000
Density 1.312g/cm3 Boiling Point 595ºC at 760 mmHg
Molecular Formula C20H20O5 Melting Point N/A
MSDS N/A Flash Point 327.7ºC

 Use of Broussochalcone A


Broussochalcone A is an antioxidant and an inhibitor of Xanthine Oxidase (IC50=2.21 μM), with free radical scavenging activity. Broussochalcone A inhibits iron-induced lipid peroxidation and nitric oxide synthesis in lipopolysaccharide (LPS) -activated macrophages. Broussochalcone A also induces Apoptosis of human renal carcinoma cells by increasing ROS levels and activating FOXO3 signaling pathways[1][2].

 Names

Name (E)-1-[2,4-dihydroxy-5-(3-methylbut-2-enyl)phenyl]-3-(3,4-dihydroxyphenyl)prop-2-en-1-one
Synonym More Synonyms

 Broussochalcone A Biological Activity

Description Broussochalcone A is an antioxidant and an inhibitor of Xanthine Oxidase (IC50=2.21 μM), with free radical scavenging activity. Broussochalcone A inhibits iron-induced lipid peroxidation and nitric oxide synthesis in lipopolysaccharide (LPS) -activated macrophages. Broussochalcone A also induces Apoptosis of human renal carcinoma cells by increasing ROS levels and activating FOXO3 signaling pathways[1][2].
Related Catalog
In Vitro Broussochalcone A (0.3, 1, and 3 μM; 10 min, 再 Fe 诱导 30 min) 在大鼠脑匀浆中抑制 Fe2+ (200 μM) 诱导的脂质过氧化[1]。 Broussochalcone A (1-30 μM; 30 min) 剂量依赖性增加 DPPH (100 μM) 的清除活性[1]。 Broussochalcone A (0.1-1 μM) 抑制细胞色素 c 还原,IC50 为 0.5 μM,这主要是由于其清除超氧阴离子活性,部分是由于其抑制黄嘌呤氧化酶活性[1]。 Broussochalcone A (1-20 μM; 24 h) 抑制亚硝酸盐的产生和 iNOS 蛋白的表达[1]。 Western Blot Analysis[1] Cell Line: LPS-activated RAW 264.7 macrophages Concentration: 1 μM, 3 μM, 10 μM, 20 μM Incubation Time: 30 min; then stimulated by LPS (1 μg/mL) for another 24 hr Result: Caused inhibition of iNOS protein expression dose-dependently. Inhibited IkBα phosphorylation.
References

[1]. Cheng Z, et al. Broussochalcone A, a potent antioxidant and effective suppressor of inducible nitric oxide synthase in lipopolysaccharide-activated macrophages. Biochem Pharmacol. 2001 Apr 15;61(8):939-46.  

[2]. Lee HK, et al. Broussochalcone A Induces Apoptosis in Human Renal Cancer Cells via ROS Level Elevation and Activation of FOXO3 Signaling Pathway. Oxid Med Cell Longev. 2021 Oct 27;2021:2800706.  

 Chemical & Physical Properties

Density 1.312g/cm3
Boiling Point 595ºC at 760 mmHg
Molecular Formula C20H20O5
Molecular Weight 340.37000
Flash Point 327.7ºC
Exact Mass 340.13100
PSA 97.99000
LogP 3.91380
Index of Refraction 1.679

 Synonyms

2-Propen-1-one,1-(2,4-dihydroxy-5-(3-methyl-2-butenyl)phenyl)-3-(3,4-dihydroxyphenyl)-,(E)
Broussochalcone A
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