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  • BioBioPha
  • China
  • Product Name: Cearoin
  • Price: ¥3400.0/5mg
  • Purity: 98.0%
  • Stocking Period: 10 Day
  • Contact: Xueping-Zheng

  • DC Chemicals Limited
  • China
  • Product Name: Cearoin
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

52811-37-7

52811-37-7 structure
52811-37-7 structure
  • Name: Cearoin
  • Chemical Name: (2,5-dihydroxy-4-methoxyphenyl)-phenylmethanone
  • CAS Number: 52811-37-7
  • Molecular Formula: C14H12O4
  • Molecular Weight: 244.24300
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2018-10-09 22:32:35
  • Modify Date: 2024-01-15 22:46:47
  • Cearoin, isolated from Dalbergia odorifera, increases autophagy and apoptosis through the production of ROS and the activation of ERK[1].

Name (2,5-dihydroxy-4-methoxyphenyl)-phenylmethanone
Description Cearoin, isolated from Dalbergia odorifera, increases autophagy and apoptosis through the production of ROS and the activation of ERK[1].
Related Catalog
Target

ERK

ROS

Autophagy

Apoptosis

In Vitro Cearoin (10-80 μM) induces cell death in a dose-dependent manner[1]. Cearoin (10-80 μM) increases the phosporylation of ERK in SH-SY5Y cells[1]. Cearoin (5-80 μM) increases the conversion of LC3B-I to LC3B-II in SH-SY5Y cells. The expression of LC3B-II is a good marker for autophagosome formation in the autophagy process[1]. Cell Viability Assay[1] Cell Line: Human neuroblastoma SH-SY5Y cells Concentration: 0, 1, 5, 10, 20, 40, or 80 μM Incubation Time: 6 or 12 hours Result: Significantly decreased cell viability from 10 μM in a dose-dependent manner. Treatment with 40 μM for 12 h induced about 50% loss in cell viability in SH-SY5Y cells. Western Blot Analysis[1] Cell Line: Human neuroblastoma SH-SY5Y cells Concentration: 0, 5, 10, 20, 40, or 80 μM Incubation Time: 12 hours Result: Increased ERK phosphorylation in a dose-dependent manner, whereas it did not alter JNK phosphorylation. Induced the formation of LC3B-II in a dose dependent manner.
References

[1]. Tonking Bastola, et al. Cearoin Induces Autophagy, ERK Activation and Apoptosis via ROS Generation in SH-SY5Y Neuroblastoma Cells. Molecules. 2017 Feb 6;22(2):242.

Density 1.296g/cm3
Boiling Point 443.8ºC at 760 mmHg
Molecular Formula C14H12O4
Molecular Weight 244.24300
Flash Point 171.7ºC
Exact Mass 244.07400
PSA 66.76000
LogP 2.33740
Index of Refraction 1.623
HS Code 2914509090
HS Code 2914509090
Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%