52811-37-7

52811-37-7 structure

Name: Cearoin
Chemical Name: (2,5-dihydroxy-4-methoxyphenyl)-phenylmethanone
CAS Number: 52811-37-7
Molecular Formula: C₁₄H₁₂O₄
Molecular Weight: 244.24300
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-10-09 22:32:35
Modify Date: 2024-01-15 22:46:47
Cearoin, isolated from Dalbergia odorifera, increases autophagy and apoptosis through the production of ROS and the activation of ERK[1].

Name	(2,5-dihydroxy-4-methoxyphenyl)-phenylmethanone

Description	Cearoin, isolated from Dalbergia odorifera, increases autophagy and apoptosis through the production of ROS and the activation of ERK[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	ERK ROS Autophagy Apoptosis
In Vitro	Cearoin (10-80 μM) induces cell death in a dose-dependent manner[1]. Cearoin (10-80 μM) increases the phosporylation of ERK in SH-SY5Y cells[1]. Cearoin (5-80 μM) increases the conversion of LC3B-I to LC3B-II in SH-SY5Y cells. The expression of LC3B-II is a good marker for autophagosome formation in the autophagy process[1]. Cell Viability Assay[1] Cell Line: Human neuroblastoma SH-SY5Y cells Concentration: 0, 1, 5, 10, 20, 40, or 80 μM Incubation Time: 6 or 12 hours Result: Significantly decreased cell viability from 10 μM in a dose-dependent manner. Treatment with 40 μM for 12 h induced about 50% loss in cell viability in SH-SY5Y cells. Western Blot Analysis[1] Cell Line: Human neuroblastoma SH-SY5Y cells Concentration: 0, 5, 10, 20, 40, or 80 μM Incubation Time: 12 hours Result: Increased ERK phosphorylation in a dose-dependent manner, whereas it did not alter JNK phosphorylation. Induced the formation of LC3B-II in a dose dependent manner.
References	[1]. Tonking Bastola, et al. Cearoin Induces Autophagy, ERK Activation and Apoptosis via ROS Generation in SH-SY5Y Neuroblastoma Cells. Molecules. 2017 Feb 6;22(2):242.

Density	1.296g/cm3
Boiling Point	443.8ºC at 760 mmHg
Molecular Formula	C₁₄H₁₂O₄
Molecular Weight	244.24300
Flash Point	171.7ºC
Exact Mass	244.07400
PSA	66.76000
LogP	2.33740
Index of Refraction	1.623

HS Code	2914509090

1378871-36-3

71-43-2

52811-37-7

Literature: Kumar, Sarvesh; Reddy L, Chandra Shekhar; Kumar, Yogesh; Kumar, Amit; Singh, Brajendra K.; Kumar, Vineet; Malhotra, Shashwat; Pandey, Mukesh K.; Jain, Rajni; Thimmulappa, Rajesh; Sharma, Sunil K.; Prasad, Ashok K.; Biswal, Shyam; Van Der Eycken, Erik; Depass, Anthony L.; Malhotra, Sanjay V.; Ghosh, Balaram; Parmar, Virinder S. Archiv der Pharmazie, 2012 , vol. 345, # 5 p. 368 - 377

131-57-7

52811-37-7

Literature: Laumas et al. Proceedings - Indian Academy of Sciences, Section A, 1957 , vol. 46, p. 343,346

52811-36-6

52811-37-7

Literature: Kulshrestha,S.K. et al. Indian Journal of Chemistry, 1974 , vol. 12, p. 10 - 14

36896-99-8

52811-37-7

Literature: Kulshrestha,S.K. et al. Indian Journal of Chemistry, 1974 , vol. 12, p. 10 - 14

Precursor 4
71-43-2 131-57-7 52811-36-6 36896-99-8
DownStream 0

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

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