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480-49-9

480-49-9 structure
480-49-9 structure
  • Name: Filipin III
  • Chemical Name: filipin III
  • CAS Number: 480-49-9
  • Molecular Formula: C35H58O11
  • Molecular Weight: 654.828
  • Catalog: Signaling Pathways Anti-infection Fungal
  • Create Date: 2018-09-20 13:03:44
  • Modify Date: 2025-08-25 11:08:09
  • Filipin III is the major component of Filipin, a 28-membered ring pentaene macrolide antifungal antibiotic produced by S. filipinensis, S. avermitilis and S. miharaensis. Filipin interacts with membrane sterols causing the alteration of membrane structure[1].
Name filipin III
Synonyms (17E,19E,21E,23E,25E)-4,6,8,10,12,14,16,27-Octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyloxacyclooctacosa-17,19,21,23,25-pentaen-2-one
Filipin III
Description Filipin III is the major component of Filipin, a 28-membered ring pentaene macrolide antifungal antibiotic produced by S. filipinensis, S. avermitilis and S. miharaensis. Filipin interacts with membrane sterols causing the alteration of membrane structure[1].
Related Catalog
Target

Fungal[1]

References

[1]. Payero TD, et al. Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives. Microb Cell Fact. 2015 Aug 7;14:114.
Density 1.2±0.1 g/cm3
Boiling Point 913.9±65.0 °C at 760 mmHg
Melting Point 163-180°C
Molecular Formula C35H58O11
Molecular Weight 654.828
Flash Point 279.3±27.8 °C
Exact Mass 654.397888
PSA 208.37000
LogP -0.41
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.536

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RN9800000
CHEMICAL NAME :
Oxacyclooctacosa-17,19,21,23,25-pentaen-2-one, 4,6,8,10,12,14,16,27-octahydroxy-3- (1-hydroxyhexyl)-17,28-dimethyl-
CAS REGISTRY NUMBER :
480-49-9
LAST UPDATED :
199709
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C35-H58-O11
MOLECULAR WEIGHT :
654.93
WISWESSER LINE NOTATION :
T-28-OV PU TU VU A&UTJ CYQ5 DQ FQ HQ JQ LQ MQ OQ P1 C&Q D&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
17 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA adduct
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport
RTECS RN9800000
Precursor  2

DownStream  0

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