480-49-9

• 常用中文名：菲律平 III
• 常用英文名：Filipin III
• CAS号：480-49-9
• 分子式：C₃₅H₅₈O₁₁
• 分子量：654.828
• 相关类别： 信号通路 抗感染 真菌
• 发布时间：2018-09-20 13:03:44
• 更新时间：2026-07-03 05:00:53
• Filipin III 是 Filipin 的主要成分,Filipin 是一种 28-元环五烯大环内酯类抗真菌抗生素,由 S. filipinensis,S. avermitilis 和 S. miharaensis 产生。Filipin 可以与膜甾醇相互作用导致膜结构的改变。

名称

• 中文名: 菲律平
• 英文名: filipin III
• 中文别名: 菲律平 III (HPLC); 菲律平III; Filipin III (Cholesterol fluorescent probe) 胆固醇荧光探针; Filipin Complex 菲律宾菌素复合物; 菲律宾菌素 III; 菲律宾菌素; 菲律宾三世; 【现货】菲律宾菌素 III/胆固醇荧光探针; 非律平III
• 英文别名: 1',26-Dihydroxyfilipin I; 16,18,20,22,24-Octacosapentenoic acid, 3,5,7,9,11,13,15,26,27-nonahydroxy-2-(1-hydroxyhexyl)-16-methyl-, 27-lactone; Nsc38092; 28-dimethyl-3-(1-hydroxyhexyl)-1; 4S,6S,8S,10R,12R,14R,16S,27S-OCTAHYDROXY-3R-(1R-HYDROXY-HEXYL)17,28R-DIMETHYL-OXACYCLOOCTACOSA-17E,19E,21E,23E,25E-PENTAEN-2-ONE; 27-lactone; FILIPIN III //BP; lFilipin III; 16;20;22;24-OCTACOSAPENTENOIC ACID; 3;5;7;9;11;13;15;26;27-NONAHYDROXY-2-(1-HYDROXYHEXYL)-16-METHYL-; 27-LACTONE; 24-Octacosapentenoic acid; 27-nonahydroxy-2-(1-hydroxyhexyl)-16-methyl; (3R,4S,6S,8S,10R,12R,14R,16S,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,16,27-octahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one; FILIPIN III; filimisin; (17E,19E,21E,23E,25E)-4,6,8,10,12,14,16,27-Octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyloxacyclooctacosa-17,19,21,23,25-pentaen-2-one; u-5956; 15-Deoxylagosin; 1'-Hydroxyfilipin II; nsc3364; 4,6,8,10,12,14,16,27-Octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyloxacyclooctacosa-17,19,21,23,25-pentaen-2-one; oxacyclooctacosa-17,19,21,23,25-pentaen-2-one,4,6,8,10,12,14,16,27-octahydroxy; Oxacyclooctacosa-17,19,21,23,25-pentaen-2-one, 4,6,8,10,12,14,16,27-octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyl; Filipin III from Strtomyces filipinensis; (3R,4S,6S,8S,10R,12R,14R,16S,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,16,27-Octahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyloxacyclooctacosa-17,19,21,23,25-pentaen-2-one; filipin iii from strtomyces*filipinensis; 1'-i-Filipin IV; Oxacyclooctacosa-17,19,21,23,25-pentaen-2-one, 4,6,8,10,12,14,16,27-octahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-, (3R,4S,6S,8S,10R,12R,14R,16S,17E,19E,21E,23E,25E,27S,28R)

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 913.9±65.0 °C at 760 mmHg
• 熔点: 163-180°C
• 分子式: C₃₅H₅₈O₁₁
• 分子量: 654.828
• 闪点: 279.3±27.8 °C
• 精确质量: 654.397888
• PSA: 208.37000
• LogP: -0.41
• 外观性状: 固体
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.536
• 储存条件: -20°C，密封，干燥，惰性气体

生物活性

• 描述: Filipin III 是 Filipin 的主要成分,Filipin 是一种 28-元环五烯大环内酯类抗真菌抗生素,由 S. filipinensis,S. avermitilis 和 S. miharaensis 产生。Filipin 可以与膜甾醇相互作用导致膜结构的改变。
• 相关类别:
  信号通路 >> 抗感染 >> 真菌
  研究领域 >> 炎症/免疫
• 靶点:

  Fungal[1]

• 参考文献:

  [1]. Payero TD, et al. Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives. Microb Cell Fact. 2015 Aug 7;14:114.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : RN9800000 CHEMICAL NAME : Oxacyclooctacosa-17,19,21,23,25-pentaen-2-one, 4,6,8,10,12,14,16,27-octahydroxy-3- (1-hydroxyhexyl)-17,28-dimethyl- CAS REGISTRY NUMBER : 480-49-9 LAST UPDATED : 199709 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C35-H58-O11 MOLECULAR WEIGHT : 654.93 WISWESSER LINE NOTATION : T-28-OV PU TU VU A&UTJ CYQ5 DQ FQ HQ JQ LQ MQ OQ P1 C&Q D&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 17 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : DNA adduct TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 10 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H315-H319-H335
• 警示性声明: P261-P305 + P351 + P338
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): 26-36
• 危险品运输编码: NONH for all modes of transport
• RTECS号: RN9800000

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