158966-92-8
158966-92-8 structure
- Name: Montelukast
- Chemical Name: montelukast
- CAS Number: 158966-92-8
- Molecular Formula: C35H36ClNO3S
- Molecular Weight: 586.183
- Catalog: API Respiratory medication Asthma
- Create Date: 2018-02-21 08:00:00
- Modify Date: 2026-07-01 09:37:19
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Montelukast is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (CysLT1). Montelukast can be used for the reseach of asthma and liver injury. Montelukast also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage[1].
| Name | montelukast |
|---|---|
| Synonyms |
Montelukast D6 sodium salt (Rac)
[3H]-Montelukast (1-{1-{3(R)-[2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid Montelukast AcidQ: What is Montelukast Acid Q: What is the CAS Number of Montelukast Acid Q: What is the storage condition of Montelukast Acid Q: What e the applications of Montelukast Acid Cyclopropaneaceticacid,1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-Methylethyl)phenyl]propyl]thio]Methyl] Monteluk Montelukast [INN:BAN] MFCD05662278 (r-(e))-1-(((1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid {1-[({(1R)-1-{3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl}sulfanyl)methyl]cyclopropyl}acetic acid Singul [14C]-Montelukast Montelukast free acid UNII-MHM278SD3E Brondilat (TN) Montelukast //BP Montelukast (R-(E))-1-(((1-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2- (1-hydroxy-1- methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid {1-[({(1R)-1-{3-[(E)-2-(7-Chloroquinolin-2-yl)vinyl]phenyl}-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl}sulfanyl)methyl]cyclopropyl}acetic acid Montelukast for System Suitability RS Montelukast - Bio-X Montair 2-[1-[[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid Montelukas Montelukast API (Sodium salt) Singular [R-(E)]-1-[[[1-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic Acid 2-[1-[[(1r)-1-[3-[(e)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid {1-[({(1R)-1-{3-[(E)-2-(7-Chloro-2-quinolinyl)vinyl]phenyl}-3-[2-(2-hydroxy-2-propanyl)phenyl]propyl}sulfanyl)methyl]cyclopropyl}acetic acid Montelukastl Montelukast (INN) Montelukast Acid Montelukast(Form A) Montelukast Sodium- IP/BP (R,E)-2-[1-[[[1-[3-[2-(7-Chloro-2-quinolyl)vinyl]phenyl]-3-[2-(2-hydroxy-2-propyl)phenyl]propyl]thio]methyl]cyclopropyl]acetic Acid |
| Description | Montelukast is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (CysLT1). Montelukast can be used for the reseach of asthma and liver injury. Montelukast also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage[1]. |
|---|---|
| Related Catalog | |
| Target |
CysLT1 |
| In Vitro | Montelukast (5 μM; 1 h) inhibits APAP-induced cell damage[1]. |
| In Vivo | Montelukast (3 mg/kg; oral gavage) protects against APAP-induced hepatotoxicity in mice[1]. Montelukast (1 mg/kg; miniosmotic pump administration) reduces the airway remodeling changes observed in OVA-treated mice and blocks the actions of cysteinyl leukotrienes (LT) C4, D4, and E4 mediated by the CysLT1 receptor[2]. Montelukast (1 mg/kg; miniosmotic pump administration) reduces the elevated levels of IL-4 and IL-13 found in the BAL fluid of OVA-treated mice[2]. Animal Model: C57BL/6J mice (8-week-old; 22-25 g) are induced acute hepatic injury[1] Dosage: 3 mg/kg Administration: Oral gavage 1 h after saline or APAP administration Result: Decreased serum levels of alanine transaminase (ALT) and aspartate aminotransferase (AST), and alleviated liver damage. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 750.5±60.0 °C at 760 mmHg |
| Molecular Formula | C35H36ClNO3S |
| Molecular Weight | 586.183 |
| Flash Point | 407.7±32.9 °C |
| Exact Mass | 585.210449 |
| PSA | 95.72000 |
| LogP | 7.80 |
| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
| Index of Refraction | 1.678 |
| Storage condition | 2-8°C |
| Hazard Codes | Xi |
|---|
| Precursor 10 | |
|---|---|
| DownStream 2 | |
![(1-{1-(R)-(3-bromophenyl)-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid structure](https://image.chemsrc.com/caspic/276/1015076-80-8.png)
![(1S)-1-{3-[(E)-2-(7-Chloro-2-quinolinyl)vinyl]phenyl}-3-[2-(2-hyd roxy-2-propanyl)phenyl]-1-propanol structure](https://image.chemsrc.com/caspic/477/287930-77-2.png)
![2-[1-(Mercaptomethyl)cyclopropyl]acetic acid structure](https://image.chemsrc.com/caspic/092/162515-68-6.png)
