74844-91-0
74844-91-0 structure
- Name: Boc-Hyp-OMe
- Chemical Name: N-Boc-trans-4-Hydroxy-L-proline methyl ester
- CAS Number: 74844-91-0
- Molecular Formula: C11H19NO5
- Molecular Weight: 245.272
- Catalog: Biochemical Amino acids and their derivatives Proline derivatives
- Create Date: 2018-02-18 08:00:00
- Modify Date: 2026-07-03 17:39:10
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Boc-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
| Name | N-Boc-trans-4-Hydroxy-L-proline methyl ester |
|---|---|
| Synonyms |
1-O-tert-butyl 2-O-methyl (2S,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate
N-Boc-trans-4-hydroxy-L-proline methyl ester N-Boc-trans-4-hydroxy-L-proline Methyl Ester trans-Boc-Hyp-OMe 1-tert-Butyl 2-Methyl (2S,4R)-4-Hydroxypyrrolidine-1,2-dicboxylate (2S,4R)-4-Hydroxypyrrolidine-1,2-dicboxylic Acid 1-tert-Butyl 2-Methyl Ester N-tert-Butoxycbonyl-L-hydroxyproline Methyl Ester N-tert-Butoxycbonyl-trans-4-hydroxy-L-proline methyl ester 1-(tert-butyl) 2-Methyl (2S,4R)-4-hydroxytetrahydro-1H-pyrrole-1,2-dicboxylate trans-N-Boc-4-hydroxy-L-proline Methyl Ester,e.e N-Boc-cis-4-Hydroxy-L-prolinem ethylester N-Boc-trans-4-Hydroxy-L-prolinemethylester (2S,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate N-Boc-cis-4-hydroxy-L-proline methyl ester cis-Boc-Hyp-OMe N-ALPHA-T-BUTOXYCBONYL-L-HYDROXYPROLINE METHYL ESTER (2S,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylic Acid 1-tert-Butyl 2-Methyl Ester N-BOC-transydro-L-prolinemethylester (Tert-Butoxy)carbonyl Hyp-OMe O1-tert-Butyl O2-methyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicboxylate (2R,4R)-4-HYDROXY-PYRROLIDINE-1,2-DICBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER N-(tert-Butoxycbonyl)-trans-4-hydroxy-L-proline methyl ester N-Boc-trans-4-hydroxy-L 1,2-Pyrrolidinedicboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2S,4R) (2S,4R)-4-Hydroxypyrrolidine-1,2-dicboxylic Acid 1-tert-Butyl 2-Methyl Ester BOC-L-4-TRANS-HYDROXYPROLINE METHYL ESTER (2S,4R)-BOC 4-HYDROXYPROLINE METHYL ESTER N-(tert-Butoxycbonyl)-trans-hydroxy-L-proline methyl ester BOC-HYP-OME / BOC-L-HYDROXYPROLINE METHYL ESTER (2S,4R)-1-tert-butyl 2-Methyl 4-hydro×ypyrrolidine-1,2-dicbo×ylate BOC-HYP-OME GOSO-001 1-(tert-butyl) 2-Methyl (2S,4R)-4-hydro×ytetrahydro-1H-pyrrole-1,2-dicbo×ylate 1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicboxylate trans-N-Boc-4-hydroxy-L-proline Methyl Ester (2S,4R)-1-(TERT-BUTOXYCBONYL)-2-CBOMETHOXY-4-HYDROXYPYRROLIDINE 1-O-tert-butyl 2-O-methyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicboxylate N-(tert-Butoxycbonyl)-trans-4-hydroxy-L-proline Methyl Ester > (2S,4R)-4-Hydroxypyrrolidine-1,2-dicboxylic Acid 1-tert-Butyl Ester 2-Methyl Ester Methyl (4R)-N-Boc-4-hydroxy-L-prolinate N-BOC-L-Hydroxyproline methyl ester N-T-BOC-TRANS-4-HYDROXY-L-PROLINE METHYL ESTER N-(tert-Butoxycarbonyl)-cis-4-hydroxy-L-proline Methyl Ester BOC-L-4-HYDROXYPROLINE METHYL ESTER BOC-L-Hyp Methyl ester N-Boc-trans-hydro-L-prolinemethylester Boc-Hyp-Ome N-BOC-TRANS-4-HYDROXY-L-PROLINE METHYL & 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicboxylate N-Boc-trans-4-Hydroxy-L-proline methyl ester //BP BOC-L-HYDROXYPROLINE METHYL ESTER Tert butoxycbonyl-l-hydroxyproline methyl ester BOC-L-T-4-HYDROXYPROLINE METHYL ESTER Boc-trans-4-hydroxy-L-proline methyl ester N-BOC-L-TRANS-4-HYDROXY-PROLINE METHYL ESTER Boc-cis-Hyp-OMe (2S,4R)-N-Boc-trans-4-hydroxy-L-proline methyl ester N-BOC-4-HYDROXY-L-PROLINE METHYL ESTER Boc-L-Hyp-OMe (2S,4R)-N-Boc-4-hydroxyproline methyl ester (2S,4R)-1-tert-butyl 2-Methyl 4-hydroxypyrrolidine-1,2-dicboxy 1-tert-Butyl 2-Methyl (2S,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylate 1-tert-butyl 2-methyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicboxylate BOC-HYDROXYPROLINE-OME N-(TERT-BUTOXYCBONYL)-TRANS-HYDROXYL-L-PROLINE METHYL ESTER (2S,4R)-1-BOC-4-hydroxy pyrrolidine-2-cboxylic acid methyl ester N-BOC-TRANS-4-HYDROXYL-L-PROLINE METHYL ESTER BOC-TRANS-4-HYDROXY-L-PROLINE METHYL ESTER MFCD00076981 (2S,4R)-1-(tert-Butoxycbonyl)-4-hydroxy-2-(methoxycbonyl)pyrrolidine, trans-1-(tert-Butoxycbonyl)-4-hydroxy-L-proline methyl ester Boc-L-4-trans-hydroxyproline methyl ester (HPLC, Chiral purity) |
| Description | Boc-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 335.2±42.0 °C at 760 mmHg |
| Melting Point | 92-96 °C(lit.) |
| Molecular Formula | C11H19NO5 |
| Molecular Weight | 245.272 |
| Flash Point | 156.6±27.9 °C |
| Exact Mass | 245.126328 |
| PSA | 76.07000 |
| LogP | -0.25 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.501 |
| Storage condition | 2~8°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xn |
| Risk Phrases | R20/21/22 |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2933990090 |
| Precursor 9 | |
|---|---|
| DownStream 10 | |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |