13726-69-7
13726-69-7 structure
- Name: Boc-Hyp-OH
- Chemical Name: Boc-L-Hydroxyproline
- CAS Number: 13726-69-7
- Molecular Formula: C10H17NO5
- Molecular Weight: 231.246
- Catalog: Biochemical Amino acids and their derivatives Proline derivatives
- Create Date: 2018-07-09 18:23:20
- Modify Date: 2026-06-30 18:39:33
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Boc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]
| Name | Boc-L-Hydroxyproline |
|---|---|
| Synonyms |
BOC-L-TRANS-4-HYDROXYPROLINE
Boc-L-trans-hydroxyproline(Boc-trans-Hyp-OH) ,(HPLC) Boc-L-trans-4-hydroxyproline (Assay) (2S,4R)-1-(tert-butoxycbonyl)-4-hydroxypyrrolidine-2-cboxylic acid N-BOC-L-Hydroxyproline N-BOC-L-TRANS-4-HYDROXYPROLINE (Tert-Butoxy)carbonyl Hyp-OH (Hyp of Animal Origin) RARECHEM EM WB 0136 trans-N-tert-Butoxycarbonyl-4-hydroxy-l-proline (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicboxylic acid 1-(tert-butyl) ester BOC-TRANS-HYP-OH N-(TERT-BUTOXYCBONYL)-L-4-HYDROXYPROLINE BOC-TRANS-4-HYDROXY-L-PROLINE N-(tert-Butoxycbonyl)-trans-4-hydroxy-L-proline N-Boc-(2S,4R)-4-hydroxyproline RECHEM EM WB 0136 TRANS-N-(TERT-BUTOXYCBONYL)-4-HYDROXY-L-PROLINE trans-N-(tert-Butoxycarbonyl)-4-hydroxy-L-proline BOC-L-T-4-HYDROXYPROLINE BOC-L-HYP-OH (2S)-1-[(tert-butoxy)carbonyl]-4-hydroxypyrrolidine-2-cboxylic acid (2S,4R)-1-(tertbutoxycbonyl-4-hydroxypyrrolidine acid Boc-4-hydroxy-L-proline N-ALPHA-T-BOC-TRANS-4-HYDROXY-L-PROLINE 1,2-Pyrrolidinedicboxylicacid,4-hydroxy-,1-(1,1-diMethylethyl)ester,(2S,4R) Boc-Hyp-OH (cryst) Novabiochem N-BOC-4-HYDROXY-L-PROLINE （2S，4R)-1-（tertbutoxycbonyl）-4-hydroxypyrrolidine cboxylic acid Boc-Hyp-OH >= (TLC) (4R)-1-(tert-Butoxycbonyl)-4-hydroxy-L-proline N-ALPHA-T-BOC-L-TRANS-4-HYDROXYPROLINE (2S,4R)-N-ALPHA-T-BUTOXYCBONYL-4-HYDROXYPYRROLIDINE-2-CBOXYLIC ACID (2S,4R)-4-Hydroxypyrrolidine-2-cboxylic acid, N-BOC protected BOC-(2S,4R)-(-)-4-HYDROXYPYRROLIDINE-2-CBOXYLIC ACID BOC-HYP-OH N-ter BOC-HYP 1-[(tert-Butoxy)carbonyl]-4-hydroxy-L-proline (Tert-Butoxy)carbonyl Hyp-OH (Hyp of Non-Animal Origin) BOC-HYPOZANTHINE extrapure N-ALPHA-T-BUTOXYCBONYL-TRANS-4-HYDROXY-L-PROLINE (2S,4R)-N-t-Butoxycbonyl-4-hydroxypyrrolidine-2-cboxylic Acid BOC-L-4-HYDROXYPROLINE Teneint-E TRANS-N-(TERT-BUTOXYCBONYL)-4-HYDROXY (2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid MFCD00053370 N-ALPHA-TERT-BUTYLOXYCBONYL-L-4-HYDROXYPROLINE N-T-BOC-TRANS-4-HYDROXY-L-PROLINE BOC-HYDROXYPROLINE Boc-(2S,4R)-4-Hydroxy-2-pyrrolidinecboxylic Acid (4R)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline 4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline N-BOC-L-4-HYDROXYPROLINE N-TERT-BUTOXYCBONYL-L-HYDROXYPROLINE BOC-L-HYDROXYPROLINE trans-Boc-Hyp-OH N-ALPHA-T-BUTOXYCBONYL-L-HYDROXYPROLINE Boc-Hyp-OH, >= BOC-trans-4-hydroxy-L-proline Butoxycbonylhydroxypyroline trans-N-Boc-4-hydroxy-L-proline trans-Boc-Hyp-OH N-BOC-TRANS-4-HYDROXY-L-PROLINE Boc-L-hydroxyproline, trans-N-(tert-Butoxycbonyl)-4-hydroxy-L-proline N-ALPHA-T-BOC-L-HYDROXYPROLINE trans-N-Boc-4-hydroxy-L-proline (2S,4R)-N-Boc-trans-4-hydroxy-L-proline 1-(tert-Butoxycarbonyl)-4-hydroxy-L-proline |
| Description | Boc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2] |
|---|---|
| Related Catalog | |
| Target |
Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 390.9±42.0 °C at 760 mmHg |
| Melting Point | 123-127 °C(lit.) |
| Molecular Formula | C10H17NO5 |
| Molecular Weight | 231.246 |
| Flash Point | 190.2±27.9 °C |
| Exact Mass | 231.110672 |
| PSA | 87.07000 |
| LogP | -0.71 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.531 |
| Storage condition | -20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xn |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2933990090 |
| Precursor 10 | |
|---|---|
| DownStream 10 | |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |