139756-21-1

139756-21-1 structure

Name: 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]-7-pyrimidinone
Chemical Name: 5-(2-Ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
CAS Number: 139756-21-1
Molecular Formula: C₁₇H₂₀N₄O₂
Molecular Weight: 312.366
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2018-12-28 06:54:06
Modify Date: 2026-07-16 14:33:10
PDE5-IN-7 (compound 8) is a selective phosphodiesterase 5 (PDE 5) inhibitor with an IC50 value of 5 nM, while an IC50 of 300 nM for PDE 1[1].

Name	5-(2-Ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Synonyms	1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H) 5-(2-ETHOXY PHENYL)-1-METHYL-3-N-PROPYL- 1 6-DIHYDRO-7H-PYRAZOLO-(4 3D)PYRIMIDINE 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(4H)-one DPX 84 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1H,4H,7H-pyrazolo[4,3-d]pyrimidin-7-one 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazole[4,3-d]pyrimidine-7-one 5-(2-ETHOXYPHENYL)-1-ME-3-N-PROPYL-1,6-DIHYDRO-7H-PYRAZOLO(4,3D)-7-PYRIMIDIN 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one 5-(2-ethoxyphenyl)-1-Methyl-3-propyl-6H-pyrazolo[4,3-d]pyriMidin-7-one 5-(2-Ethoxypheny1)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one UK 088800, 10 mM in DMSO 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 5-(2-ETHOXYPHENYL)-1-METHYL-3-N-PROPYL-1 5-(2-ETHOXYPHENYL)-1-METHYL-3-N-PROPYL-1,6-DIHYDRO-7H-PYRAZOLO[4,3-D]-7-PYRIMIDINONE 5-(2-ethoxyphenyl)-1-methyl-3-propyl 5-(2-Ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]-7-pyrimidinone 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]-7-pyrimidinone CAS NO.139-1 5-(2-Ethoxyphenyl)-1-Methyl-3-N-Propyl-1,6-Dihydro-7H-Pyrazo 5-(2-Ethoxyphenyl)-1-Methyl-3-propyl-1H-pyrazolo[4,3-d]pyriMidin-7(6H)-one 5-(2-Ethoxy Phenyl)-1,6-Dihydro-1-MethyI-3-Propyl-7H-Pyrazolo-[4,3-d] Pyrimidin-7-one 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one Sildenafil impurity E(Sildenafil Lactam Impurity) Tianfu Chem 5-(2-ETHOXYPHENYL)-1-METHYL-3-N-PROPYL-1,6-DIHYDRO-7H-PYRAZOLO[4,3-D]-7-PYRIMIDINONE Sildenafil LactaM IMpurity 5-(2-Ethoxyphenyl) 7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE,5-(2-ETHOXYPHENYL)-1,4-DIHYDRO-1-METHYL-3-PROPYL 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 5-(2-ETHOXYPHENYL)-1-METHYL-3-N-PROPYL-1,6-DIHYDRO-7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7-ol Sildenafil citrate impurity L 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one (EMP) PDE5-IN-7 7H-Pyrazolo[4,3-d]pyrimidin-7-one, 5-(2-ethoxyphenyl)-1,6-dihydro-1-methyl-3-propyl 5-(2-ethoxyphenyl)-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7h-pyrazolo[4,3-d]-7-pyrimidinone 5-(2-Ethoxyphenyl)-1-methyl-prop Sildenafil pyrimidinone 5-(2-Ethoxyphenyl)-l-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolol- 4,3-dipyrimidin-7-one

Description	PDE5-IN-7 (compound 8) is a selective phosphodiesterase 5 (PDE 5) inhibitor with an IC50 value of 5 nM, while an IC50 of 300 nM for PDE 1[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Others
Target	PDE5:5 nM (IC50) PDE1:300 nM (IC50)
In Vitro	PDE5-IN-7 (compound 15, Desild) can be detected and isolated from Sildenafil (HY-15025) derivatives[2].

Density	1.3±0.1 g/cm3
Boiling Point	504ºC at 760 mmHg
Melting Point	141-145ºC(lit.)
Molecular Formula	C₁₇H₂₀N₄O₂
Molecular Weight	312.366
Flash Point	258.6ºC
Exact Mass	312.158630
PSA	72.80000
LogP	2.38
Vapour Pressure	2.75E-10mmHg at 25°C
Index of Refraction	1.632

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933990090

Precursor 10
139756-03-9 613-69-4 139756-02-8 42926-52-3
139756-01-7 36983-31-0 139755-99-0 133261-07-1
139756-00-6 134-11-2
DownStream 6
371959-09-0 479074-06-1 1058653-74-9 139755-85-4
139755-83-2 139756-22-2

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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