913842-25-8

913842-25-8 structure

Name: Lu-aa47070
Chemical Name: Lu AA47070
CAS Number: 913842-25-8
Molecular Formula: C₁₇H₂₀F₂N₃O₆PS
Molecular Weight: 463.39
Create Date: 2018-04-19 18:42:30
Modify Date: 2024-01-09 19:15:40
Lu AA47070 is a phosphonooxymethylene prodrug of a potent and selective Adenosine A2A receptor antagonist. Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade[1][2].

Name	Lu AA47070
Synonyms	phosphoric acid mono{2-[(E/Z)-4-(3,3-dimethylbutyrylamino)-3,5-difluorobenzoylimino]thiazol-3-ylmethyl} ester phosphoric acid mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} ester LU-AA47070

Description	Lu AA47070 is a phosphonooxymethylene prodrug of a potent and selective Adenosine A2A receptor antagonist. Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
In Vivo	Lu AA47070 (3.75、7.5、15、30 mg/kg；腹腔注射) 逆转由亚慢性给药 D2 拮抗剂匹莫齐特（1.0 mg/kg；腹腔注射）引起的下颌颤动、僵直和运动抑制[2]< /sup>。 Animal Model: Male Sprague Dawley rats[2] Dosage: 3.75, 7.5, 15, 30 mg/kg Administration: I.p. Result: Reversed the tremulous jaw movements, catalepsy, and locomotor suppression induced by subchronic administration of the D2 antagonist pimozide (1.0 mg/kg IP).
References	[1]. Discovery of Phosphoric Acid Mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} Ester (Lu AA47070): A Phosphonooxymethylene Prodrug of a Potent and Selective hA2A Receptor AntagonistJ. Med. Chem., Article ASAPDOI: 10.1021/jm1008659Publication Date (Web): January 6, 2011 [2]. Collins LE, et al. The novel adenosine A2A antagonist Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade. Pharmacol Biochem Behav. 2012 Jan;100(3):498-505.