65144-34-5

65144-34-5 structure

Name: SPCK
Chemical Name: methoxysuccinyl-Ala-Ala-Pro-Val chloromethyl ketone
CAS Number: 65144-34-5
Molecular Formula: C₂₂H₃₅ClN₄O₇
Molecular Weight: 502.98900
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cathepsin
Create Date: 2017-04-10 15:04:33
Modify Date: 2025-08-30 08:23:06
MeOSuc-AAPV-CMK (Elastase Inhibitor III) is an elastase inhibitor. MeOSuc-AAPV-CMK also inhibits cathepsin G and proteinase 3.MeOSuc-AAPV-CMK blocks the cleavage of adiponectin by leukocyte elastase[1].

Name	methoxysuccinyl-Ala-Ala-Pro-Val chloromethyl ketone
Synonyms	methyl 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(3S)-1-chloro-4-methyl-2-oxopentan-3-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoate MeOSuc-Ala-Ala-Pro-Val-CMK Meosuc-aapv-cmk Methoxy-suc-ala-ala-pro-val-chloromethyl ketone Msaapvck methoxysuccinyl-alanyl-alanyl-prolyl-valine chloromethyl ketone Elastase Inhibitor,SPCK MeOSuc-Ala-Ala-Pro-Val-chloromethylketone

Description	MeOSuc-AAPV-CMK (Elastase Inhibitor III) is an elastase inhibitor. MeOSuc-AAPV-CMK also inhibits cathepsin G and proteinase 3.MeOSuc-AAPV-CMK blocks the cleavage of adiponectin by leukocyte elastase[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Metabolic Enzyme/Protease >> Elastase Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin
References	[1]. Waki H, et al. Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1. Endocrinology. 2005 Feb;146(2):790-6. [2]. Middelhoven PJ, Vet al. Different proteolytic mechanisms involved in Fc gamma RIIIb shedding from human neutrophils. Clin Exp Immunol. 2001 Jul;125(1):169-75.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	3