5092-09-1

5092-09-1 structure

Name: Saikogenin A
Chemical Name: (3S,4R,4aR,6aR,6bS,8S,8aS,14aS,14bS)-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,14a-dodecahydropicene-3,8-diol
CAS Number: 5092-09-1
Molecular Formula: C₃₀H₄₈O₄
Molecular Weight: 472.700
Catalog: Signaling Pathways Metabolic Enzyme/Protease Dipeptidyl Peptidase
Create Date: 2018-02-16 08:00:00
Modify Date: 2024-01-13 14:18:37
Saikogenin A, extracted from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV (DPP-IV) inhibitor.

Name	(3S,4R,4aR,6aR,6bS,8S,8aS,14aS,14bS)-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,14a-dodecahydropicene-3,8-diol
Synonyms	Oleana-11,13(18)-diene-3,16,23,28-tetrol, (3β,16β)- (3β,4α,16β)-Oleana-11,13(18)-diene-3,16,23,28-tetrol saikogenin A (3β,16β)-Oleana-11,13(18)-diene-3,16,23,28-tetrol

Description	Saikogenin A, extracted from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV (DPP-IV) inhibitor.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase Research Areas >> Metabolic Disease Research Areas >> Inflammation/Immunology Natural Products >> Terpenoids and Glycosides
Target	DPP-IV[1]
In Vitro	Saikogenin A has certain inhibitory effect on the enzyme DPP-IV. At a concentration of 20 μg/mL DPP-IV inhibition is 47.6%. DPP-IV is a non-classical serine aminopeptidase from its amino terminus of polypeptides and proteins (N-terminus) removing Xaa-Pro dipeptide[1].
In Vivo	Saikogenin A, an anti-inflammatory drug, is present in the crude extract of a Chinese herbal plant called Tsai-Fu. Saikogenin A is less effective in adrenalectomized rats than in normal rats in reducing the carrageenin-induced edema. The anti-inflammatory action of Saikogenin A are due to an increase in corticosterone caused by the release of arenocorticotropic hormone (ACTH) and a direct effect on the process of inflammation[2].
References	[1]. Pharmaceutical application of saikogenin A. CN107375300A. [2]. Cheng JT, et al. Anti-inflammatory effect of Saikogenin A. Biochem Pharmacol. 1986 Aug 1;35(15):2483-7.