38954-02-8

38954-02-8 structure

Name: Icariside D2
Chemical Name: icariside D2
CAS Number: 38954-02-8
Molecular Formula: C₁₄H₂₀O₇
Molecular Weight: 300.30400
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2018-02-08 12:35:03
Modify Date: 2024-01-06 17:11:50
Icariside D2, isolated from Annona glabra fruit, inhibits angiotensin-converting enzyme. Icariside D2 shows significant cytotoxic activity on the HL-60 cell line with the IC50 value of 9.0 ± 1.0 μM. Icariside D2 induces apoptosis [1][2].

Name	icariside D2
Synonyms	p-(2'-hydroxyethyl)-phenol β-D-pyranoglucoside 2-(4'-β-D-glucopyranosyloxy)-phenylethanol 2-(4'-β-glucopyranosyloxy)phenylethanol icariside D2 icariside D2 salidroside

Description	Icariside D2, isolated from Annona glabra fruit, inhibits angiotensin-converting enzyme. Icariside D2 shows significant cytotoxic activity on the HL-60 cell line with the IC50 value of 9.0 ± 1.0 μM. Icariside D2 induces apoptosis [1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Research Areas >> Inflammation/Immunology
In Vitro	Icariside D2 3 induces apoptosis via alteration of expression of apoptosis-related proteins and decreases phosphorylation of AKT in HL-60 cells[1]. Icariside D2 exhibits anti-inflammatory and anti-HIV activity[3].
References	[1]. Nguyen Thi Thu Hien, et al. Chemical Constituents of the Annona Glabra Fruit and Their Cytotoxic Activity. Pharm Biol. 2015;53(11):1602-7. [2]. Xue Liu, et al. Metabolic Engineering Escherichia coli for Efficient Production of Icariside D2. Biotechnol Biofuels. 2019 Nov 6;12:261. [3]. Jin-YuLi, et al. Three new acylated prenylflavonol glycosides from Epimedium koreanum. Phytochemistry Letters Volume 17, September 2016, Pages 206-212.

Hazard Codes	Xi