Henan Tianfu Chemical Co., Ltd.
China
Product Name: Pyridoxine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson
Email: info@tianfuchem.com

65-23-6

65-23-6 structure

Name: Pyridoxine
Chemical Name: pyridoxine
CAS Number: 65-23-6
Molecular Formula: C₈H₁₁NO₃
Molecular Weight: 169.178
Catalog: API Vitamins and minerals Vitamin B drugs
Create Date: 2018-08-01 10:55:24
Modify Date: 2026-07-01 18:08:05
Pyridoxine is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

Name	pyridoxine
Synonyms	2-Picoline-4,5-dimethanol, 3-hydroxy 4,5-Bis(hydroxymethyl)-2-methyl-3-pyridinol 3-Hydroxy-4,5-dimethylol-alpha-picoline Brillian-VB6 PYRIDOXINE HYDROCHLORIDE RENAUDIN LABOTEST-BB LT00244779 Pirivitol 2-methyl-3-hydroxy-4,5-dihydroxymethylpyridine 3-Hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine 2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin PYRIDOXOL Pyridoxine (Vitamin B6) Bezatin 5-hydroxy-6-methyl-4-pyridinedimethanol PYRIDOXINE FREE BASE PYRIDOXOL HCL PYRIDOXINE HCL 3-hydroxy-2-picoline-5-dimethanol 2-methyl-3-hydroxy-4,5-bis(hydroxy-methyl) pyridine Beesix 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl 3-HYDROXY-4,5-DIMETHYLOL-2-PICOLINE HYDROCHLORIDE 3-Hydroxy-4,5-dimethylol-a-picoline Pyridoxine,Pyridoxol, VitaminB6 EINECS 200-386-2 4,5-BIS-HYDROXYMETHYL-2-METHYL-PYRIDIN-3-OL Nimati B6 hydrochloride Pyridoxine hydrochloride 5-Hydroxy-6-mehtyl-3,4-pyridinedimethanol 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol ADERMINE HYDROCHLORIDE Pridoxine B6-HCL ADEMINE HCL 4,5-BIS(HYDROXYMETHYL)-2-METHYL-3-PYRIDINOL 5-HYDROXY-6-METHYL-3,4-PYRIDINEDIMETHANOL HYDROCHLORIDE PYRIDOXIN HYDROCHLORIDE Vitamin B6 2-Methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine VITAMIN B6 HYDROCHLORIDE B6-PYRIDOXINE HYDROCHLORIDE Vitamin B6VVitamin B6itamin B6Vitamin B6B6 Vitamin B6 Solution Vitamine B6, Pyridoxine HCL PYRIDOXIN avidox 3-hydroxy-2-Picoline-4,5-dimethanol Hydoxin PN HCL Hexabion ADERMINE 3-Hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine hydrochloride VITAMIN B6(PYRIDOXINE HCL)(SH) VIT B6 PYRIDOXINE 3,4-PYRIDINEDIMETHANOL, 5 HYDROXY-6-METHYL-HYDROCHLORIDE 5-Hydroxy-6-methyl-3,4-pyridinedimethanol (5-hydroxy-6-Methylpyridine-3,4-diyl)diMethanol ADERMINE, HCL 4,5-Di(hydroxymethyl)-2-methylpyridin-3-ol Pyridoxol 3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine VITAMIN B6 COMPLEX Pyridoxol, VitaminB6 2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine Adermin VITAMIN B6(PYRIDOXINE)(P) (5-Hydroxy-6-methylpyridine-3,4-diyl)dimethanol MFCD00006335 VITAMIN B6, HCL

Description	Pyridoxine is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Neurological Disease Natural Products >> Others
Target	Human Endogenous Metabolite
In Vitro	Pyridoxine exerts a protective potential against AD, attenuates ROS levels, decreases the expressions of cytoplasmic Nrf2, and upregulates whole-cell HO-1 expression[1].
References	[1]. Li C, et al. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway. Cell Mol Biol (Noisy-le-grand). 2018 Jul 30;64(10):119-124.

Density	1.4±0.1 g/cm3
Boiling Point	491.9±40.0 °C at 760 mmHg
Melting Point	159-162ºC
Molecular Formula	C₈H₁₁NO₃
Molecular Weight	169.178
Flash Point	251.3±27.3 °C
Exact Mass	169.073898
PSA	73.58000
LogP	-1.10
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.621
Storage condition	2-8°C
Stability	Stable. Incompatible with strong oxidizing agents.
Water Solubility	H2O: 0.1 g/mL at 20 °C, clear, colorless

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV1300000

CHEMICAL NAME :: Pyridoxol

CAS REGISTRY NUMBER :: 65-23-6

LAST UPDATED :: 199707

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C8-H11-N-O3

MOLECULAR WEIGHT :: 169.20

WISWESSER LINE NOTATION :: T6NJ B1 CQ D1Q E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 2100 mg/kg/30D-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - paresthesis Behavioral - ataxia

REFERENCE :: NEURAI Neurology. (Modern Medicine Pub., Inc., 1 E. First St., Duluth, MN 55802) V.1- 1951- Volume(issue)/page/year: 35,1466,1985

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 4800 mg/kg/17W-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - local anesthetic

REFERENCE :: NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 309,445,1983

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 139 mg/kg/5Y-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - paresthesis

REFERENCE :: NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 311,986,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 5143 mg/kg/17W-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - local anesthetic

REFERENCE :: NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 309,445,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 43,116,1940

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 4,179,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3100 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 43,116,1940

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 657 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 44,147,1940

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 966 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 40,371,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 545 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,683,1960 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4524 No. of Facilities: 630 (estimated) No. of Industries: 3 No. of Occupations: 12 No. of Employees: 14045 (estimated) No. of Female Employees: 5607 (estimated)

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UV1350000
HS Code	29362500

Precursor 7
479-30-1 18872-74-7 100193-34-8 2397-71-9
18724-73-7 5442-82-0 100313-76-6
DownStream 10
82-82-6 66-72-8 5196-20-3 10030-93-0
1464-33-1 16133-22-5 25183-10-2 6560-46-9
922170-18-1 95735-51-6

HS Code	2936250000
Summary	HS: 2936250000. (5-hydroxy-6-methylpyridine-3,4-diyl)dimethanol. VAT:17.0%. tax rebate rate:13.0%. supervision conditions:ab(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tarrif:4.0%. general tariff:20.0%

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