110659-91-1

110659-91-1 structure

Name: Psammaplin A
Chemical Name: OT-Key 21539
CAS Number: 110659-91-1
Molecular Formula: C₂₂H₂₄Br₂N₄O₆S₂
Molecular Weight: 664.38700
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-02-08 09:36:10
Modify Date: 2024-01-12 15:21:06
Psammaplin A, a marine metabolite, is a potent inhibitor of HDAC and DNA methyltransferases. Psammaplin A ia a highly potent and selective DAC1 inhibitor with an IC50 of 0.9 nM. Psammaplin A possess the antimicrobial effect on the Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Antitumor Activity[1][2].

Name	OT-Key 21539
Synonyms	3-(3-Bromo-4-hydroxy-phenyl)-N-[2-(2-{3-(3-bromo-4-hydroxy-phenyl)-2-[(Z)-hydroxyimino]-propionylamino}-ethyldisulfanyl)-ethyl]-2-[(Z)-hydroxyimino]-propionamide Li0061 bisprasin psammaplin A

Description	Psammaplin A, a marine metabolite, is a potent inhibitor of HDAC and DNA methyltransferases. Psammaplin A ia a highly potent and selective DAC1 inhibitor with an IC50 of 0.9 nM. Psammaplin A possess the antimicrobial effect on the Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Antitumor Activity[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC Signaling Pathways >> Epigenetics >> DNA Methyltransferase Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 0.9 nM (DAC1)[1]
References	[1]. Matthias G J Baud, et al. Defining the Mechanism of Action and Enzymatic Selectivity of Psammaplin A Against Its Epigenetic Targets. J Med Chem. 2012 Feb 23;55(4):1731-50. [2]. Psammaplin A, a Natural Bromotyrosine Derivative From a Sponge, Possesses the

Hazard Codes	Xi