Psammaplin A

Modify Date: 2024-01-12 15:21:06

Psammaplin A Structure
Psammaplin A structure
Common Name Psammaplin A
CAS Number 110659-91-1 Molecular Weight 664.38700
Density N/A Boiling Point N/A
Molecular Formula C22H24Br2N4O6S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Psammaplin A


Psammaplin A, a marine metabolite, is a potent inhibitor of HDAC and DNA methyltransferases. Psammaplin A ia a highly potent and selective DAC1 inhibitor with an IC50 of 0.9 nM. Psammaplin A possess the antimicrobial effect on the Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Antitumor Activity[1][2].

 Names

Name OT-Key 21539
Synonym More Synonyms

 Psammaplin A Biological Activity

Description Psammaplin A, a marine metabolite, is a potent inhibitor of HDAC and DNA methyltransferases. Psammaplin A ia a highly potent and selective DAC1 inhibitor with an IC50 of 0.9 nM. Psammaplin A possess the antimicrobial effect on the Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Antitumor Activity[1][2].
Related Catalog
Target

IC50: 0.9 nM (DAC1)[1]

References

[1]. Matthias G J Baud, et al. Defining the Mechanism of Action and Enzymatic Selectivity of Psammaplin A Against Its Epigenetic Targets. J Med Chem. 2012 Feb 23;55(4):1731-50.

[2]. Psammaplin A, a Natural Bromotyrosine Derivative From a Sponge, Possesses the

 Chemical & Physical Properties

Molecular Formula C22H24Br2N4O6S2
Molecular Weight 664.38700
Exact Mass 661.95000
PSA 214.44000
LogP 4.46400

 Safety Information

Hazard Codes Xi

 Synonyms

3-(3-Bromo-4-hydroxy-phenyl)-N-[2-(2-{3-(3-bromo-4-hydroxy-phenyl)-2-[(Z)-hydroxyimino]-propionylamino}-ethyldisulfanyl)-ethyl]-2-[(Z)-hydroxyimino]-propionamide
Li0061
bisprasin
psammaplin A
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