1219177-18-0

1219177-18-0 structure

Name: Thalidomide D4
Chemical Name: 4,5,6,7-tetradeuterio-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
CAS Number: 1219177-18-0
Molecular Formula: C₁₃H₆D₄N₂O₄
Molecular Weight: 262.25400
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-08-14 18:20:14
Modify Date: 2025-08-20 14:45:38
Thalidomide D4 is a deuterium labeled Thalidomide. Thalidomide is initially promoted as a sedative, inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties[1][2].

Name	4,5,6,7-tetradeuterio-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Synonyms	\|A-Phthalimidoglutarimide-d4 Myrin-d4 3-Phthalimidoglutarimide-d4 Celgene-d4 Contergan-d4 Thalidomide-d4 Distaval-d4 Kevadon-d4

Description	Thalidomide D4 is a deuterium labeled Thalidomide. Thalidomide is initially promoted as a sedative, inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	Kd: ~250 nM (CRL4CRBN)[1]
References	[1]. Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. [2]. Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203.