Thalidomide D4

Modify Date: 2024-01-24 15:54:33

Thalidomide D4 Structure
Thalidomide D4 structure
Common Name Thalidomide D4
CAS Number 1219177-18-0 Molecular Weight 262.25400
Density N/A Boiling Point N/A
Molecular Formula C13H6D4N2O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Thalidomide D4


Thalidomide D4 is a deuterium labeled Thalidomide. Thalidomide is initially promoted as a sedative, inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties[1][2].

 Names

Name 4,5,6,7-tetradeuterio-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Synonym More Synonyms

 Thalidomide D4 Biological Activity

Description Thalidomide D4 is a deuterium labeled Thalidomide. Thalidomide is initially promoted as a sedative, inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties[1][2].
Related Catalog
Target

Kd: ~250 nM (CRL4CRBN)[1]

References

[1]. Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.

[2]. Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203.

 Chemical & Physical Properties

Molecular Formula C13H6D4N2O4
Molecular Weight 262.25400
Exact Mass 262.08900
PSA 87.04000
LogP 0.30160

 Synonyms

|A-Phthalimidoglutarimide-d4
Myrin-d4
3-Phthalimidoglutarimide-d4
Celgene-d4
Contergan-d4
Thalidomide-d4
Distaval-d4
Kevadon-d4