Thalidomide D4

Modify Date: 2024-01-24 15:54:33

Thalidomide D4 structure	Common Name	Thalidomide D4
	CAS Number	1219177-18-0	Molecular Weight	262.25400
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₃H₆D₄N₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Thalidomide D4

Thalidomide D4 is a deuterium labeled Thalidomide. Thalidomide is initially promoted as a sedative, inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties[1][2].

Name	4,5,6,7-tetradeuterio-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Synonym	More Synonyms

Description	Thalidomide D4 is a deuterium labeled Thalidomide. Thalidomide is initially promoted as a sedative, inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	Kd: ~250 nM (CRL4CRBN)[1]
References	[1]. Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. [2]. Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203.

Molecular Formula	C₁₃H₆D₄N₂O₄
Molecular Weight	262.25400
Exact Mass	262.08900
PSA	87.04000
LogP	0.30160

|A-Phthalimidoglutarimide-d4

Myrin-d4

3-Phthalimidoglutarimide-d4

Celgene-d4

Contergan-d4

Thalidomide-d4

Distaval-d4

Kevadon-d4

Thalidomide D4

Use of Thalidomide D4

Names

Thalidomide D4 Biological Activity

Chemical & Physical Properties

Synonyms