Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Metoprolol fumarate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

80274-67-5

80274-67-5 structure

80274-67-5 structure

Name: Metoprolol fumarate
Chemical Name: Metoprolol fumarate
CAS Number: 80274-67-5
Molecular Formula: C₁₉H₂₉NO₇
Molecular Weight: 383.436
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-06-19 19:22:39
Modify Date: 2024-01-02 10:56:13
Metoprolol fumarate (CGP 2175C) is an orally active, selective β1-adrenoceptor antagonist. Metoprolol fumarate shows anti-inflammation, antitumor and anti-angiogenic properties[1][2][3].

Name	Metoprolol fumarate
Synonyms	Metoprolol hemifumarate 1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]-2-propanol (2E)-2-butenedioate (1:1) 2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (2E)-2-butenedioate (1:1) (salt) Metoprolol fumarate

Description	Metoprolol fumarate (CGP 2175C) is an orally active, selective β1-adrenoceptor antagonist. Metoprolol fumarate shows anti-inflammation, antitumor and anti-angiogenic properties[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Endocrinology Research Areas >> Infection Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	β1 adrenoceptor
In Vitro	Metoprolol (0-1000 μg/mL; 24-72 h) shows cytotoxic effect on U937 and MOLT-4 cells dose and time dependently[3]. Cell Cytotoxicity Assay[3] Cell Line: U937 and MOLT-4 cells Concentration: 1, 10, 50, 100, 500 and 1000 μg/mL Incubation Time: 24, 48 and 72 h Result: Significantly decreased the viability of U937 and MOLT-4 cells at 1000 μg/mL (3740.14µM) concentration after 48 hours incubation time, significantly reduced the viability of U937 cells at ≥500 μg/ml (≥1870.07µM) concentrations after 72 hours incubation time, and significantly decreased the viability of MOLT4 cells at ≥100 μg/ml (≥374.01µM) concentrations after 72 hours incubation.
In Vivo	Metoprolol (2.5 mg/kg/h; infusion; 11 weeks) reduces proinflammatory cytokines and atherosclerosis in ApoE−/− Mice[1]. Metoprolol (15 mg/kg/q12h; i.g.; 5 days) shows anti-inflammation and anti-virus effects in murine model with coxsackievirus B3-induced viral myocarditis[2]. Metoprolol (2.5 mg/kg; i.v.; 3 bolus injections) significantly decreased activated caspase-9 protein expression and inhibits myocardial apoptosis in coronary microembolization (CME) rats[4]. Animal Model: Male ApoE−/− mice[1] Dosage: 2.5 mg/kg/h Administration: Via osmotic minipumps, 11 weeks Result: Significantly reduced atherosclerotic plaque area in thoracic aorta, reduced serum TNFα and the chemokine CXCL1 as well as decreasing the macrophage content in the plaques. Animal Model: Balb/c mice, coxsackievirus B3 (CVB3) induced viral myocarditis (VMC) model[2] Dosage: 15 mg/kg/q12h Administration: Oral gavage, 5 consecutive days Result: Reduced pathological scores of VMC induced by CVB3 infection, protected the myocardium against viral damage by reducing serum cTn-I levels. Decreased the levels of myocardial pro-inflammatory cytokines and increase the expression of anti-inflammatory cytokine. Significantly decreased myocardial virus titers.
References	[1]. Ulleryd MA, et al. Metoprolol reduces proinflammatory cytokines and atherosclerosis in ApoE-/- mice. Biomed Res Int. 2014;2014:548783. [2]. Wang D, et al. Carvedilol has stronger anti-inflammation and anti-virus effects than metoprolol in murine model with coxsackievirus B3-induced viral myocarditis. Gene. 2014 Sep 1;547(2):195-201. [3]. Hajatbeigi B, et al. Cytotoxicity of Metoprolol on Leukemic Cells in Vitro. IJBC 2018; 10(4): 124-129. [4]. Su Q, et al. Effect of metoprolol on myocardial apoptosis and caspase-9 activation after coronary microembolization in rats. Exp Clin Cardiol. 2013 Spring;18(2):161-5.

Molecular Formula	C₁₉H₂₉NO₇
Molecular Weight	383.436
Exact Mass	383.194397