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143-24-8

143-24-8 structure
143-24-8 structure
  • Name: Me-PEG4-Me
  • Chemical Name: tetraglyme
  • CAS Number: 143-24-8
  • Molecular Formula: C10H22O5
  • Molecular Weight: 222.279
  • Catalog: Chemical reagent Organic reagent Ether
  • Create Date: 2018-04-23 08:00:00
  • Modify Date: 2025-08-20 19:58:28
  • Me-PEG4-Me is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Name tetraglyme
Synonyms tetraglyme
Dimethyltetraglycol
Bis[2-(2-methoxyethoxy)ethyl] ether
MFCD00008505
2,5,8,11,14-Pentaoxapentadecane
EINECS 205-594-7
1-methoxy-2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethane
2,5,8,11,14-Pentaoxapentadecane (Bis[2-(2-methoxyethoxy)ethyl] ether
Dimethoxytetraethylene glycol
Tetraethylene glycol dimethyl ether
Description Me-PEG4-Me is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Density 1.0±0.1 g/cm3
Boiling Point 275.3±0.0 °C at 760 mmHg
Melting Point −30 °C(lit.)
Molecular Formula C10H22O5
Molecular Weight 222.279
Flash Point 140.6±0.0 °C
Exact Mass 222.146729
PSA 46.15000
LogP -1.51
Vapour density 7.7 (vs air)
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.421

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SB0400000
CHEMICAL NAME :
2,5,8,11,14-Pentaoxapentadecane
CAS REGISTRY NUMBER :
143-24-8
BEILSTEIN REFERENCE NO. :
1760005
LAST UPDATED :
199710
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C10-H22-O5
MOLECULAR WEIGHT :
222.32
WISWESSER LINE NOTATION :
1O2O2O2O2O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5140 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
1000 ppm/7H
SEX/DURATION :
male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 70,303,1983
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
1000 ppm/7H
SEX/DURATION :
male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 70,303,1983
Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H360Df
Precautionary Statements P201-P308 + P313
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi:Irritant;
Risk Phrases R19;R43
Safety Phrases S36-S24
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS SB0400000
HS Code 2942000000
111-77-3 structure

111-77-3

~%

143-24-8 structure

143-24-8

Literature: Barnakov, Ch. N.; Volgin, A. A. Russian Journal of Applied Chemistry, 1993 , vol. 66, # 1.2 p. 152 - 155 Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1993 , vol. 66, # 1 p. 182 - 185
75-21-8 structure

75-21-8

115-10-6 structure

115-10-6

~0%

110-71-4 structure

110-71-4

112-49-2 structure

112-49-2

Detail
Literature: WO2005/87695 A1, ; Page/Page column 7-9 ;
638-56-2 structure

638-56-2

124-41-4 structure

124-41-4

~%

143-24-8 structure

143-24-8

Literature: Bulletin de la Societe Chimique de France, , p. 844,846 Journal de Chimie Physique et de Physico-Chimie Biologique, , vol. 54, p. 421,424
115-10-6 structure

115-10-6

~%

112-49-2 structure

112-49-2

111-96-6 structure

111-96-6

143-24-8 structure

143-24-8

Literature: WO2006/134081 A1, ; Page/Page column 6 ;
111-44-4 structure

111-44-4

~%

143-24-8 structure

143-24-8

Literature: Industrial and Engineering Chemistry, , vol. 29, p. 548 Chem. Zentralbl., , vol. 109, # I p. 4534 US2111234 , ;
HS Code 2901100000
Summary 2901100000 saturated acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%
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