151358-47-3
151358-47-3 structure
- Name: DIM-C-pPhOH
- Chemical Name: 7,7-bis(3-indolyl)-p-cresol
- CAS Number: 151358-47-3
- Molecular Formula: C23H18N2O
- Molecular Weight: 338.402
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-01-08 00:00:11
- Modify Date: 2024-01-11 17:55:15
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DIM-C-pPhOH is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhOH inhibits cancer cell growth and mTOR signaling, induce apoptosis and cellular stress. DIM-C-pPhOH reduces cell proliferation with IC50 values of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells, respectively[1].
| Name | 7,7-bis(3-indolyl)-p-cresol |
|---|---|
| Synonyms |
Phenol, 4-(di-1H-indol-3-ylmethyl)-
4-(Di-1H-indol-3-ylmethyl)phenol 7,7-bis(3-indolyl)-p-cresol |
| Description | DIM-C-pPhOH is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhOH inhibits cancer cell growth and mTOR signaling, induce apoptosis and cellular stress. DIM-C-pPhOH reduces cell proliferation with IC50 values of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
Nuclear receptor 4A1 (NR4A1)[1] |
| In Vitro | DIM-C-pPhOH (7.5-20 μM; 24 hours; ACHN and 786-O cells) treatment significantly decreases cell proliferation[1]. DIM-C-pPhOH (20 μM; 24 hours; ACHN and 786-O cells) treatment induces Annexin V staining in ACHN and 786-O cells, confirming that DIM-C-pPhOH induce apoptosis, and also induces cleavage of caspases 7 and 8[1]. DIM-C-pPhOH (15-20 μM; 24 hours; ACHN and 786-O cells) treatment inhibits NR4A1-regulated expression of survivin, bcl-2 and EGFR in ACHN and 786-O cells. And also induces sestrin 2, activates AMPKα and inhibits activation of mTOR and downstream kinases[1]. DIM-C-pPhOH decreases expression of β1-integrin protein and mRNA and β1-integrin-dependent responses in MCF7, MDA-MB-231, and SKBR3 cells and also inhibits migration of the latter two cell lines[2]. Cell Proliferation Assay[1] Cell Line: ACHN and 786-O cells Concentration: 7.5 μM, 15 μM, 20 μM Incubation Time: 24 hours Result: Significantly decreased cell proliferation. Apoptosis Analysis[1] Cell Line: ACHN and 786-O cells Concentration: 20 μM Incubation Time: 24 hours Result: Induced apoptosis in ACHN and 786-O cells. Western Blot Analysis[1] Cell Line: ACHN and 786-O cells Concentration: 15 μM, 20 μM Incubation Time: 24 hours Result: Inhibited NR4A1-regulated expression of survivin, bcl-2 and EGFR in ACHN and 786-O cells. And also induced sestrin 2, activated AMPKα and inhibited activation of mTOR and downstream kinases. |
| In Vivo | DIM-C-pPhOH (30 mg/kg; oral gavage; daily; for 50 days; male athymic nude mice) treatment results in a significant inhibition of tumor growth[1]. Animal Model: Male athymic nude mice (aged 6-7 weeks) injected with ACHN cells[1] Dosage: 30 mg/kg/day Administration: Oral gavage; daily; for 50 days Result: Resulted in a significant inhibition of tumor growth. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 610.2±50.0 °C at 760 mmHg |
| Molecular Formula | C23H18N2O |
| Molecular Weight | 338.402 |
| Flash Point | 322.9±30.1 °C |
| Exact Mass | 338.141907 |
| LogP | 4.80 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.770 |
| Hazard Codes | Xi |
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