80449-31-6

80449-31-6 structure

Name: Ulinastatin
Chemical Name: 3-(2-Furyl)-2,4-dioxaspiro[5.5]undec-8-ene
CAS Number: 80449-31-6
Molecular Formula: C₁₃H₁₆O₃
Molecular Weight: 220.264
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-01-24 12:07:28
Modify Date: 2024-01-04 09:17:15
Ulinastatin (Uristatin) is a trypsin and serine protease inhibitor. Ulinastatin is the main protein binding inhibitor of various trypsin, chymotrypsin, and various pancreatic proteases. Ulinastatin shows neuroprotective, anti-inflammatory, anti-apoptotic, anti-oxidant effects[1][2].

Name	3-(2-Furyl)-2,4-dioxaspiro[5.5]undec-8-ene
Synonyms	3-(2-Furyl)-2,4-dioxaspiro[5.5]undec-8-ene 2,4-Dioxaspiro[5.5]undec-8-ene, 3-(2-furanyl)- Ulinastatin

Description	Ulinastatin (Uristatin) is a trypsin and serine protease inhibitor. Ulinastatin is the main protein binding inhibitor of various trypsin, chymotrypsin, and various pancreatic proteases. Ulinastatin shows neuroprotective, anti-inflammatory, anti-apoptotic, anti-oxidant effects[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
References	[1]. Shangping Fang, et al. Research progress of ulinastatin in the treatment of liver diseases. Int J Clin Exp Pathol. 2020 Nov 1;13(11):2720-2726. [2]. Cao C, et al. Ulinastatin Protects Against LPS-Induced Acute Lung Injury By Attenuating TLR4/NF-κB Pathway Activation and Reducing Inflammatory Mediators. Shock. 2018 Nov;50(5):595-605.