235082-52-7

235082-52-7 structure

Name: MEN 11270
Chemical Name: D-Arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-N-[(8S,13S,15aS,22aR)-13-(3-carbamimidamidopropyl)-7,12,15,22-tetraoxo-5,8,9,10,11,12,13,14,15,15a,16,16a,17,18,19,20,20a,22,22a,23-icosahydro-7H-indolo[1',2':4,5][1,4,7,10]tetraazacyclotetradecino[1,2-b]isoquinolin-8-yl]-3-(2-thienyl)-D-alaninamide
CAS Number: 235082-52-7
Molecular Formula: C₆₀H₉₀N₂₀O₁₁S
Molecular Weight: 1299.55
Create Date: 2018-07-15 13:28:34
Modify Date: 2024-02-26 20:10:45
MEN 11270, a cyclic decapeptide, is a B2 kinin receptor antagonist. MEN 11270 bound with high-affinity to the B2 kinin receptor constitutively expressed by WI38 human fibroblasts, inhibiting 3H-bradykinin (BK) with a pKi value of 10.3[1].

Name	D-Arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-N-[(8S,13S,15aS,22aR)-13-(3-carbamimidamidopropyl)-7,12,15,22-tetraoxo-5,8,9,10,11,12,13,14,15,15a,16,16a,17,18,19,20,20a,22,22a,23-icosahydro-7H-indolo[1',2':4,5][1,4,7,10]tetraazacyclotetradecino[1,2-b]isoquinolin-8-yl]-3-(2-thienyl)-D-alaninamide
Synonyms	D-Alaninamide, D-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-N-[(8S,13S,15aS,22aR)-13-[3-[(aminoiminomethyl)amino]propyl]-5,8,9,10,11,12,13,14,15,15a,16,16a,17,18,19,20,20a,22,22a,23-eicosahydro-7,12,15,22-tetraoxo-7H-indolo[1',2':4,5][1,4,7,10]tetraazacyclotetradecino[1,2-b]isoquinolin-8-yl]-3-(2-thienyl)- D-Arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-N-[(8S,13S,15aS,22aR)-13-(3-carbamimidamidopropyl)-7,12,15,22-tetraoxo-5,8,9,10,11,12,13,14,15,15a,16,16a,17,18,19,20,20a,22,22a,23-icosahydro-7H-indolo[1',2':4,5][1,4,7,10]tetraazacyclotetradecino[1,2-b]isoquinolin-8-yl]-3-(2-thienyl)-D-alaninamide

Description	MEN 11270, a cyclic decapeptide, is a B2 kinin receptor antagonist. MEN 11270 bound with high-affinity to the B2 kinin receptor constitutively expressed by WI38 human fibroblasts, inhibiting 3H-bradykinin (BK) with a pKi value of 10.3[1].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Bradykinin Receptor
References	[1]. Meini S, et, al. MEN 11270, A novel selective constrained peptide antagonist with high affinity at the human B2 kinin receptor. J Pharmacol Exp Ther. 1999 Jun;289(3):1250-6.