745055-86-1

745055-86-1 structure

Name: UBP 296
Chemical Name: 2-[[3-(2-amino-2-carboxyethyl)-2,6-dioxo-1-pyrimidinyl]methyl]benzoic acid
CAS Number: 745055-86-1
Molecular Formula: C₁₅H₁₅N₃O₆
Molecular Weight: 333.30
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2018-06-16 21:02:14
Modify Date: 2024-01-15 04:41:54
UBP296 is a potent and selective antagonist of GLUK5-containing kainate receptor in the spinal cord. UBP296 reversibly blocks ATPA-induced depressions of synaptic transmission, and affects AMPA receptor-mediated synaptic transmission directly in rat hippocampal slices[1].

Name	2-[[3-(2-amino-2-carboxyethyl)-2,6-dioxo-1-pyrimidinyl]methyl]benzoic acid
Synonyms	2-{[3-(2-Amino-2-carboxyethyl)-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl]methyl}benzoic acid 1(2H)-Pyrimidinepropanoic acid, α-amino-3-[(2-carboxyphenyl)methyl]-3,4-dihydro-2,4-dioxo- 2-[[3-(2-amino-2-carboxyethyl)-2,6-dioxo-1-pyrimidinyl]methyl]benzoic acid 2-{[3-(2-Amino-2-carboxyethyl)-2,6-dioxo-3,6-dihydro-1(2H)-pyrimidinyl]methyl}benzoic acid

Description	UBP296 is a potent and selective antagonist of GLUK5-containing kainate receptor in the spinal cord. UBP296 reversibly blocks ATPA-induced depressions of synaptic transmission, and affects AMPA receptor-mediated synaptic transmission directly in rat hippocampal slices[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	IC50: 3.5 ± 1.5 μM (GLUK5), 4.0 ± 0.7 μM (GLUK5/GLUK6), 7.0 ± 5.1 μM (GLUK5/GLUK2)[1]
References	[1]. More JC, et al. Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist. Neuropharmacology. 2004 Jul;47(1):46-64.