Name | (4-{[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)[4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone |
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Synonyms |
(4-{[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)[4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone
Methanone, [4-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]- MFCD09320899 |
Description | Smurf1-IN-A01 (A01) is an ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) inhibitor with a kd of 3.664 nM, which increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation[1]. |
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Related Catalog | |
Target |
Kd: 3.664 nM (Smurf1)[1] |
References |
Density | 1.5±0.1 g/cm3 |
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Boiling Point | 642.3±65.0 °C at 760 mmHg |
Molecular Formula | C22H20ClF3N4O3S |
Molecular Weight | 512.93 |
Flash Point | 342.2±34.3 °C |
Exact Mass | 512.089661 |
LogP | 3.87 |
Vapour Pressure | 0.0±1.9 mmHg at 25°C |
Index of Refraction | 1.627 |
Storage condition | 2-8℃ |
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H315-H319-H335 |
Precautionary Statements | P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313 |
RIDADR | NONH for all modes of transport |