1007647-73-5
1007647-73-5 structure
- Name: A01
- Chemical Name: (4-{[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)[4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone
- CAS Number: 1007647-73-5
- Molecular Formula: C22H20ClF3N4O3S
- Molecular Weight: 512.93
- Catalog: Research Areas Others
- Create Date: 2018-06-28 14:16:26
- Modify Date: 2024-01-07 00:23:27
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Smurf1-IN-A01 (A01) is an ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) inhibitor with a kd of 3.664 nM, which increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation[1].
| Name | (4-{[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)[4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone |
|---|---|
| Synonyms |
(4-{[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)[4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone
Methanone, [4-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]- MFCD09320899 |
| Description | Smurf1-IN-A01 (A01) is an ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) inhibitor with a kd of 3.664 nM, which increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation[1]. |
|---|---|
| Related Catalog | |
| Target |
Kd: 3.664 nM (Smurf1)[1] |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 642.3±65.0 °C at 760 mmHg |
| Molecular Formula | C22H20ClF3N4O3S |
| Molecular Weight | 512.93 |
| Flash Point | 342.2±34.3 °C |
| Exact Mass | 512.089661 |
| LogP | 3.87 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.627 |
| Storage condition | 2-8℃ |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313 |
| RIDADR | NONH for all modes of transport |