114014-15-2

114014-15-2 structure

Name: Cathepsin L inhibitor III
Chemical Name: Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE
CAS Number: 114014-15-2
Molecular Formula: C₃₁H₃₄N₄O₅
Molecular Weight: 542.63
Catalog: Signaling Pathways Anti-infection SARS-CoV
Create Date: 2018-06-05 08:25:01
Modify Date: 2024-01-12 13:53:36
Z-Phe-Tyr(tBu)-diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr(tBu)-diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection[1][2].

Name	Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE
Synonyms	Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE

Description	Z-Phe-Tyr(tBu)-diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr(tBu)-diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin
Target	cathepsin L
In Vitro	Z-Phe-Tyr(tBu)-diazomethylketone (3.3, 10 µM; 3 h) 在L929 细胞中导致呼肠孤病毒对病毒外衣壳蛋白的蛋白水解分解效率低下，并降低病毒产量[1]。 Z-Phe-Tyr(tBu)-diazomethylketone 在 SARS-CoV-2 感染心肌细胞 (CM) 中将病毒检出率降低至处理对照组的10%[2]。
References	[1]. Ebert DH, et al. Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells. J Biol Chem. 2002 Jul 5;277(27):24609-17. [2]. Perez-Bermejo JA, et al. SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19. Sci Transl Med. 2021 Apr 21;13(590):eabf7872.