Cathepsin L inhibitor III

Modify Date: 2024-01-12 13:53:36

Cathepsin L inhibitor III structure	Common Name	Cathepsin L inhibitor III
	CAS Number	114014-15-2	Molecular Weight	542.63
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₁H₃₄N₄O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Cathepsin L inhibitor III

Z-Phe-Tyr(tBu)-diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr(tBu)-diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection[1][2].

Name	Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE
Synonym	More Synonyms

Description	Z-Phe-Tyr(tBu)-diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr(tBu)-diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin
Target	cathepsin L
In Vitro	Z-Phe-Tyr(tBu)-diazomethylketone (3.3, 10 µM; 3 h) 在L929 细胞中导致呼肠孤病毒对病毒外衣壳蛋白的蛋白水解分解效率低下，并降低病毒产量[1]。 Z-Phe-Tyr(tBu)-diazomethylketone 在 SARS-CoV-2 感染心肌细胞 (CM) 中将病毒检出率降低至处理对照组的10%[2]。
References	[1]. Ebert DH, et al. Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells. J Biol Chem. 2002 Jul 5;277(27):24609-17. [2]. Perez-Bermejo JA, et al. SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19. Sci Transl Med. 2021 Apr 21;13(590):eabf7872.

Molecular Formula	C₃₁H₃₄N₄O₅
Molecular Weight	542.63
Storage condition	-15°C

Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE

DC Chemicals Limited
China
Product Name: Cathepsin L inhibitor III
Price: $700.0/100mg $1200.0/250mg $2100.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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