Cathepsin L inhibitor III

Modify Date: 2024-01-12 13:53:36

Cathepsin L inhibitor III Structure
Cathepsin L inhibitor III structure
Common Name Cathepsin L inhibitor III
CAS Number 114014-15-2 Molecular Weight 542.63
Density N/A Boiling Point N/A
Molecular Formula C31H34N4O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Cathepsin L inhibitor III


Z-Phe-Tyr(tBu)-diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr(tBu)-diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection[1][2].

 Names

Name Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE
Synonym More Synonyms

 Cathepsin L inhibitor III Biological Activity

Description Z-Phe-Tyr(tBu)-diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr(tBu)-diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection[1][2].
Related Catalog
Target

cathepsin L

In Vitro Z-Phe-Tyr(tBu)-diazomethylketone (3.3, 10 µM; 3 h) 在L929 细胞中导致呼肠孤病毒对病毒外衣壳蛋白的蛋白水解分解效率低下,并降低 病毒产量[1]。 Z-Phe-Tyr(tBu)-diazomethylketone 在 SARS-CoV-2 感染心肌细胞 (CM) 中将病毒检出率降低至处理对照组的10%[2]。
References

[1]. Ebert DH, et al. Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells. J Biol Chem. 2002 Jul 5;277(27):24609-17.  

[2]. Perez-Bermejo JA, et al. SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19. Sci Transl Med. 2021 Apr 21;13(590):eabf7872.  

 Chemical & Physical Properties

Molecular Formula C31H34N4O5
Molecular Weight 542.63
Storage condition -15°C

 Synonyms

Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE
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