204140-01-2

204140-01-2 structure

Name: MMP-9/MMP-13 INHIBITOR I
Chemical Name: MMP-9/MMP-13 INHIBITOR I
CAS Number: 204140-01-2
Molecular Formula: C₂₅H₂₅N₃O₆S
Molecular Weight: 495.55
Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
Create Date: 2018-07-13 08:12:56
Modify Date: 2024-01-03 18:34:46
MMP-9/MMP-13 Inhibitor I is a potent MMP-9 and MMP-13 inhibitor with IC50s of both 0.9 nM. MMP-9/MMP-13 Inhibitor I shows >20-folds selectivity for MMP-9/MMP-13 over other MMPs[1].

Name	MMP-9/MMP-13 INHIBITOR I

Description	MMP-9/MMP-13 Inhibitor I is a potent MMP-9 and MMP-13 inhibitor with IC50s of both 0.9 nM. MMP-9/MMP-13 Inhibitor I shows >20-folds selectivity for MMP-9/MMP-13 over other MMPs[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
Target	MMP-9:0.9 nM (IC50) MMP-13:0.9 nM (IC50) MMP-1:43 nM (IC50) MMP-3:23 nM (IC50) MMP-7:931 nM (IC50)
In Vitro	MMP-9/MMP-13 Inhibitor I (化合物 35) 抑制 MMP-1、MMP-3 和 MMP-7，IC50 值分别为 43 nM、23 nM 和 931 nM[1]。
References	[1]. M Cheng, et al. Design and synthesis of piperazine-based matrix metalloproteinase inhibitors. J Med Chem. 2000 Feb 10;43(3):369-80.