28500-04-1

28500-04-1 structure

Name: Malvidin-3-O-arabinoside chloride
Chemical Name: Malvidin-3-O-arabinoside chloride
CAS Number: 28500-04-1
Molecular Formula: C₂₂H₂₃O_11.Cl
Molecular Weight: 498.864
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2018-12-24 20:11:39
Modify Date: 2024-01-18 14:03:49
Malvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy[1].

Name	Malvidin-3-O-arabinoside chloride
Synonyms	5,7-Dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-3-chromeniumyl D-arabinopyranoside chloride D-Arabinopyranoside, 5,7-dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-1-benzopyrylium-3-yl, chloride (1:1)

Description	Malvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy[1].
Related Catalog	Signaling Pathways >> Epigenetics >> AMPK Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology Signaling Pathways >> PI3K/Akt/mTOR >> AMPK Research Areas >> Metabolic Disease
In Vitro	Malvidin-3-O-arabinoside chloride (M3A chloride, 50-400 μM) pretreatment remarkably upregulates LAMP-1 expression, which indicates elevated lysosomal mass. M3A also successfully restores lysosomal acidity and subsequently strengthenes lysosomal functions. M3A stimulates phosphorylation of AMP-activated protein kinase (AMPK), a master regulator of autophagy[1]. Cell Autophagy Assay[1] Cell Line: Caco-2 cell line. Concentration: 50, 100, 200 and 400 μM. Incubation Time: 24 h (then treated with or without 10 μM chloroquine (CQ) for another 1 h). Result: Notably inhibited excess ROS generation. 200 μM and 400 μM M3A pretreatment significantly enhanced 14% and 16% of GSH level. Enhanced autophagy flux. Significantly up-regulate the LC3-II/LC3-I ratio.
References	[1]. Yuting Li, et al. Malvidin-3-O-arabinoside ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy. Food Funct. 2020 Dec 1;11(12):10317-10328.