1609392-27-9
1609392-27-9 structure
- Name: Tyk2-IN-4(BMS986165)
- Chemical Name: Tyk2-IN-4
- CAS Number: 1609392-27-9
- Molecular Formula: C20H19D3N8O3
- Molecular Weight: 425.46
- Catalog: Signaling Pathways Epigenetics JAK
- Create Date: 2019-01-20 02:32:41
- Modify Date: 2024-01-03 16:53:34
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Tyk2-IN-4 is a selective, potent, allosteric inhibitor of tyrosine kinase 2 (Tyk2).
| Name | Tyk2-IN-4 |
|---|
| Description | Tyk2-IN-4 is a selective, potent, allosteric inhibitor of tyrosine kinase 2 (Tyk2). |
|---|---|
| Related Catalog | |
| Target |
Tyk2 |
| In Vitro | Tyk2-IN-4 blocks receptor-mediated Tyk2 activation by stabilizing the regulatory pseudokinase domain of the protein[1]. |
| In Vivo | Lupus-like disease is strongly inhibited in NZB/W mice treated with Tyk2-IN-4. Tyk2-IN-4 is safe and overall well-tolerated. There are no serious adverse events and the frequency of non-serious adverse events are similar in the active (75%) and placebo (76%) groups. After oral administration, Tyk2-IN-4 is rapidly absorbed and exhibits an apparent elimination half-life of 8-15 hours[1]. |
| References |
| Molecular Formula | C20H19D3N8O3 |
|---|---|
| Molecular Weight | 425.46 |