50932-20-2
50932-20-2 structure
- Name: Verproside
- Chemical Name: VERPROSIDE
- CAS Number: 50932-20-2
- Molecular Formula: C22H26O13
- Molecular Weight: 498.43
- Catalog: Biochemical Chinese herbal medicine ingredients
- Create Date: 2019-01-20 21:17:27
- Modify Date: 2024-01-02 20:33:47
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Verproside, a catalpol derivative iridoid glycoside isolated from the genus Pseudolysimachion, represses TNF-α -induced MUC5AC expression by inhibiting NF-κB activation via the IKK/IκB signaling cascade. Verproside has potent anti-inflammatory, antioxidant, antinociceptive activities and ir is a potent anti-asthmatic/COPD drug candidate in vivo[1].
| Name | VERPROSIDE |
|---|
| Description | Verproside, a catalpol derivative iridoid glycoside isolated from the genus Pseudolysimachion, represses TNF-α -induced MUC5AC expression by inhibiting NF-κB activation via the IKK/IκB signaling cascade. Verproside has potent anti-inflammatory, antioxidant, antinociceptive activities and ir is a potent anti-asthmatic/COPD drug candidate in vivo[1]. |
|---|---|
| Related Catalog | |
| Target |
NF-κB TNF-α IKK |
| In Vitro | Verproside (2.5-20 μM; for 2 hours) markedly reduces phosphorylation levels of IKKα/β, IκBα, and TAK1 in the 5-20 μM range[1]. Western Blot Analysis[1] Cell Line: NCI-H292 cells Concentration: 2.5, 5, 10, 20 μM Incubation Time: 2 hours Result: Resulted in markedly reduced phosphorylation levels of IKKα/β, IκBα, and TAK1. |
| In Vivo | Verproside (Intragastrically; 30 mg/kg; 48 hours) significantly reduces the immunoglobulin E (IgE) levels of verproside-treated mice[2]. Animal Model: Specific pathogen-free female BALB/c mice aged 8-10 weeks[2] Dosage: 30 mg/kg Administration: Intragastrically; 48 hours Result: Reduced significantly the immunoglobulin E (IgE) levels. |
| References |
| Density | 1.75±0.1 g/cm3(Predicted) |
|---|---|
| Boiling Point | 822.9±65.0 °C(Predicted) |
| Molecular Formula | C22H26O13 |
| Molecular Weight | 498.43 |
| Storage condition | ?20°C |
