Verproside
Modify Date: 2024-01-02 20:33:47
Verproside structure
|
Common Name | Verproside | ||
|---|---|---|---|---|
| CAS Number | 50932-20-2 | Molecular Weight | 498.43 | |
| Density | 1.75±0.1 g/cm3(Predicted) | Boiling Point | 822.9±65.0 °C(Predicted) | |
| Molecular Formula | C22H26O13 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of VerprosideVerproside, a catalpol derivative iridoid glycoside isolated from the genus Pseudolysimachion, represses TNF-α -induced MUC5AC expression by inhibiting NF-κB activation via the IKK/IκB signaling cascade. Verproside has potent anti-inflammatory, antioxidant, antinociceptive activities and ir is a potent anti-asthmatic/COPD drug candidate in vivo[1]. |
| Name | VERPROSIDE |
|---|
| Description | Verproside, a catalpol derivative iridoid glycoside isolated from the genus Pseudolysimachion, represses TNF-α -induced MUC5AC expression by inhibiting NF-κB activation via the IKK/IκB signaling cascade. Verproside has potent anti-inflammatory, antioxidant, antinociceptive activities and ir is a potent anti-asthmatic/COPD drug candidate in vivo[1]. |
|---|---|
| Related Catalog | |
| Target |
NF-κB TNF-α IKK |
| In Vitro | Verproside (2.5-20 μM; for 2 hours) markedly reduces phosphorylation levels of IKKα/β, IκBα, and TAK1 in the 5-20 μM range[1]. Western Blot Analysis[1] Cell Line: NCI-H292 cells Concentration: 2.5, 5, 10, 20 μM Incubation Time: 2 hours Result: Resulted in markedly reduced phosphorylation levels of IKKα/β, IκBα, and TAK1. |
| In Vivo | Verproside (Intragastrically; 30 mg/kg; 48 hours) significantly reduces the immunoglobulin E (IgE) levels of verproside-treated mice[2]. Animal Model: Specific pathogen-free female BALB/c mice aged 8-10 weeks[2] Dosage: 30 mg/kg Administration: Intragastrically; 48 hours Result: Reduced significantly the immunoglobulin E (IgE) levels. |
| References |
| Density | 1.75±0.1 g/cm3(Predicted) |
|---|---|
| Boiling Point | 822.9±65.0 °C(Predicted) |
| Molecular Formula | C22H26O13 |
| Molecular Weight | 498.43 |
| Storage condition | ?20°C |