2271413-06-8

2271413-06-8 structure

Name: HDACs/mTOR Inhibitor 1
Chemical Name: HDACs/mTOR Inhibitor 1
CAS Number: 2271413-06-8
Molecular Formula: C₂₈H₃₈N₈O₅
Molecular Weight: 566.65
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2019-03-30 14:28:33
Modify Date: 2024-01-12 17:57:20
HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo[1].

Name	HDACs/mTOR Inhibitor 1

Description	HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo[1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC1:0.19 nM (IC50) HDAC6:1.8 nM (IC50) mTOR:1.2 nM (IC50)
References	[1]. Chen Y, et al. Discovery of a Novel Dual Histone Deacetylases (HDACs) and Mammalian Target of Rapamycin (mTOR) Target Inhibitor as a Promising Strategy for Cancer Therapy. J Med Chem. 2019 Jan 10.

Molecular Formula	C₂₈H₃₈N₈O₅
Molecular Weight	566.65

Hazard Codes	Xi