1883299-62-4

1883299-62-4 structure

Name: PF-06700841
Chemical Name: PF-06700841
CAS Number: 1883299-62-4
Molecular Formula: C₁₈H₂₁F₂N₇O
Molecular Weight: 389.40
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2019-03-30 17:33:33
Modify Date: 2024-01-18 20:08:24
PF-06700841 is a dual JAK1 and TYK2 inhibitor with IC50s of 17 and 23 nM, respectively. Anti-inflammatory activity[1].

Name	PF-06700841

Description	PF-06700841 is a dual JAK1 and TYK2 inhibitor with IC50s of 17 and 23 nM, respectively. Anti-inflammatory activity[1].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
Target	IC50: 17 nM (JAK1), 23 nM (TYK2)[1]
References	[1]. Fensome A, et al. Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841). J Med Chem. 2018 Oct 11;61(19):8597-8612.