Name | Tyk2-IN-5 |
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Description | Tyk2-IN-5 (compound 6) is a highly potent, selective and orally active Tyk2 inhibitor and targets the JH2 domain, with a Ki of 0.086 nM for Tyk2 JH2 and an IC50 of 25 nM for IFNα. Highly effective in inhibiting IFNγ production in a rat pharmacodynamics model and fully efficacious in a rat adjuvant arthritis model[1]. |
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Related Catalog | |
Target |
Tyk2 JH2:0.086 nM (Ki) IFNα:25 nM (IC50) |
References |
Molecular Formula | C21H19FN8O2 |
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Molecular Weight | 434.43 |